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The Colombo Twin and Singleton Study (COTASS): Piloting the Feasibility of Collecting Nutritional Data and Extension of the Sample to Include Children of Twins.
Dissanayake, Lasith; Herath, Binoli; Opatha, Janani; Jabir, Sameeha; Siriwardana, Rajindra; Sirisena, Kavish; Wickramasinghe, Malmi; Wimalasekera, Manouri; Liyanage, Ruvini; Duminda Guruge, G N; Jayaweera, Kaushalya; Jayawardena, Ranil; Zavos, Helena M S; Sumathipala, Athula; Rijsdijk, Frühling.
Affiliation
  • Dissanayake L; Institute for Research and Development in Health and Social Care, No. 393/3, Lily Avenue, Off Robert Gunawardena Mawatha, Battaramulla, Colombo, Sri Lanka. chinthana89@gmail.com.
  • Herath B; Institute for Research and Development in Health and Social Care, No. 393/3, Lily Avenue, Off Robert Gunawardena Mawatha, Battaramulla, Colombo, Sri Lanka.
  • Opatha J; Health and Wellness Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
  • Jabir S; Institute for Research and Development in Health and Social Care, No. 393/3, Lily Avenue, Off Robert Gunawardena Mawatha, Battaramulla, Colombo, Sri Lanka.
  • Siriwardana R; Institute for Research and Development in Health and Social Care, No. 393/3, Lily Avenue, Off Robert Gunawardena Mawatha, Battaramulla, Colombo, Sri Lanka.
  • Sirisena K; Institute for Research and Development in Health and Social Care, No. 393/3, Lily Avenue, Off Robert Gunawardena Mawatha, Battaramulla, Colombo, Sri Lanka.
  • Wickramasinghe M; Laboratory of Nutritional Biochemistry, National Institute of Fundamental Studies, Kandy, Sri Lanka.
  • Wimalasekera M; Institute for Research and Development in Health and Social Care, No. 393/3, Lily Avenue, Off Robert Gunawardena Mawatha, Battaramulla, Colombo, Sri Lanka.
  • Liyanage R; Laboratory of Nutritional Biochemistry, National Institute of Fundamental Studies, Kandy, Sri Lanka.
  • Duminda Guruge GN; Department of Health Promotion, Faculty of Applied Sciences, Rajarata University, Mihintale, Sri Lanka.
  • Jayaweera K; Institute for Research and Development in Health and Social Care, No. 393/3, Lily Avenue, Off Robert Gunawardena Mawatha, Battaramulla, Colombo, Sri Lanka.
  • Jayawardena R; Department of Physiology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
  • Zavos HMS; Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Sumathipala A; Institute for Research and Development in Health and Social Care, No. 393/3, Lily Avenue, Off Robert Gunawardena Mawatha, Battaramulla, Colombo, Sri Lanka.
  • Rijsdijk F; Faculty of Medicine & Health Sciences, Research Institute for Primary Care & Health Sciences, Keele University, Keele, UK.
Behav Genet ; 54(1): 63-72, 2024 Jan.
Article de En | MEDLINE | ID: mdl-38184818
ABSTRACT
Nutrition and diet are key modifiable risk factors for the rising burden of non-communicable diseases like cardio-vascular diseases and diabetes in low- and middle- income countries (LMICs). The nutritional transition in dietary behaviours in LMICs has most likely contributed to this problem. Although traditionally assumed to be environmental, dietary choices are also genetically influenced. Twin study designs can be used to investigate the relative influence of genes and environment on nutrition intake, eating behaviours and associated psychological health. The overall aim of this project is to provide proof-of-concept for the feasibility of using dietary (biomarker) data within the Children-of-Twin design in nutrition studies, develop laboratory skills and statistical genetic skills and establish a Sri Lankan-specific food composition database. Currently, a pilot study is being conducted with 304 individuals (38 Monozygotic twin pairs, 38 Dizygotic twin pairs and their male or female adult offspring). Questionnaire data on nutritional intake, eating behaviours, psychological well-being, physical health, and bio-specimens are being collected. A Sri Lankan-specific food composition database was developed, training sessions on macro and micro element analysis in biological samples and statistical genetics skills development were conducted and Community Engagement and Involvement programs were carried out in two districts of Sri Lanka.
Sujet(s)
Mots clés

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Jumeaux dizygotes / Jumeaux monozygotes Type d'étude: Risk_factors_studies Limites: Adult / Female / Humans / Male Langue: En Journal: Behav Genet Année: 2024 Type de document: Article Pays d'affiliation: Sri Lanka Pays de publication: États-Unis d'Amérique

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Jumeaux dizygotes / Jumeaux monozygotes Type d'étude: Risk_factors_studies Limites: Adult / Female / Humans / Male Langue: En Journal: Behav Genet Année: 2024 Type de document: Article Pays d'affiliation: Sri Lanka Pays de publication: États-Unis d'Amérique