The Tumor Immune Microenvironment plays a Key Role in Driving the Progression of Cholangiocarcinoma.
Curr Cancer Drug Targets
; 24(7): 681-700, 2024.
Article
de En
| MEDLINE
| ID: mdl-38213139
ABSTRACT
Cholangiocarcinoma (CCA) is an epithelial cancer distinguished by bile duct cell differentiation and is also a fibroproliferative tumor. It is characterized by a dense mesenchyme and a complex tumor immune microenvironment (TME). The TME comprises both cellular and non-cellular components. The celluar component includes CCA cells, immune cells and mesenchymal cells represented by the cancer-associated fibroblasts (CAFs), while the non-cellular component is represented by mesenchymal elements such as the extracellular matrix (ECM). Recent studies have demonstrated the important role of the TME in the development, progression, and treatment resistance of CCA. These cell-associated prognostic markers as well as intercellular connections, may serve as potential therapeutic targets and could inspire new treatment approaches for CCA in the future. This paper aims to summarize the current understanding of CCA's immune microenvironment, focusing on immune cells, mesenchymal cells, ECM, intercellular interactions, and metabolism within the microenvironment.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs des canaux biliaires
/
Cholangiocarcinome
/
Évolution de la maladie
/
Microenvironnement tumoral
Limites:
Animals
/
Humans
Langue:
En
Journal:
Curr Cancer Drug Targets
Sujet du journal:
ANTINEOPLASICOS
/
NEOPLASIAS
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine