Management of second ipsilateral breast tumor event: An advocacy for a randomized trial.
Cancer Radiother
; 28(2): 188-194, 2024 Apr.
Article
de En
| MEDLINE
| ID: mdl-38216433
ABSTRACT
For a second ipsilateral breast tumor event, salvage mastectomy is the standard of care while second conservative treatment is a possible option. However, level 1 proofs are missing, leading to perform salvage mastectomy for patients who could receive second conservative treatment and consequently avoid psychological/quality of life salvage mastectomy deleterious impacts. A phase 3 randomized trial comparing salvage mastectomy to second conservative treatment is needed. Here we discuss what would be to us the optimal design of such trial to confirm the non-inferiority between the two salvage options, with a focus on methodological aspects in terms of patient characteristics and statistical issues.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs du sein
/
Mastectomie
Type d'étude:
Clinical_trials
Aspects:
Patient_preference
Limites:
Female
/
Humans
Langue:
En
Journal:
Cancer Radiother
Sujet du journal:
NEOPLASIAS
/
RADIOTERAPIA
Année:
2024
Type de document:
Article
Pays de publication:
France