Undescribed α-pyrone-containing mycotoxins and an eremophilane-type sesquiterpenoid isolated from Aspergillus aureoterreus and their cytotoxicity.
Phytochemistry
; 219: 113989, 2024 Mar.
Article
de En
| MEDLINE
| ID: mdl-38218305
ABSTRACT
Four previously undescribed and highly oxygenated α-pyrone-containing mycotoxins designated citreoviridins (EâH), and an unreported eremophilane-type sesquiterpenoid namely aureoterrolide N, were isolated from the culture broth of Aspergillus aureoterreus. Those isolates were inferred from extensive spectroscopic methods and theoretical computation, where their absolute configurations were unambiguously determined by coupling constants following an empirical rule for the acyclic vicinal diol, theoretical ECD calculation, and NMR computation using the GIAO method and DP4+ analysis. Among them, citreoviridins EâH are four stereoisomers of a citreoviridin derivative, featuring a methylated α-pyrone, an oxidized polyene linker, and a tetrahydrofuran ring. Cytotoxicity assay of all isolates demonstrated that aureoterrolide N exhibited weak inhibitory effect against human cancer cell line HL-60 with an inhibition rate of 55.2% at 40.0 µM.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Aspergillus
/
Sesquiterpènes
/
Mycotoxines
Limites:
Humans
Langue:
En
Journal:
Phytochemistry
Année:
2024
Type de document:
Article
Pays de publication:
Royaume-Uni