Integrative bioinformatics analysis identifies APOB as a critical biomarker in coronary in-stent restenosis.
Biomark Med
; 17(23): 983-998, 2023 12.
Article
de En
| MEDLINE
| ID: mdl-38223945
ABSTRACT
Aim:
Coronary artery disease (CAD) is a major contributor to the worldwide prevalence of cardiovascular disease. In-stent restenosis (ISR) is a common complication which can lead to stent implantation failure, necessitating repeated intervention and presenting a significant obstacle for CAD management.Methods:
To accurately assess and determine the hub genes associated with ISR, CAD databases from the Gene Expression Omnibus were utilized and weighted gene coexpression network analysis was employed to identify key genes in blood samples.Results:
APOB was identified as a risk gene for ISR occurrence. Subsequent correlation analysis of APOB demonstrated a positive association with ISR. Clinical validation further confirmed the predictive value of APOB in ISR detection.Conclusion:
We have identified APOB as a critical predictive biomarker for ISR in CAD patients.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladie des artères coronaires
/
Resténose coronaire
/
Intervention coronarienne percutanée
/
Valvulopathies
Type d'étude:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Humans
Langue:
En
Journal:
Biomark Med
Sujet du journal:
BIOQUIMICA
/
MEDICINA
Année:
2023
Type de document:
Article