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Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure.
Guirette, Mélanie; Lan, Jessie; McKeown, Nicola M; Brown, Michael R; Chen, Han; de Vries, Paul S; Kim, Hyunju; Rebholz, Casey M; Morrison, Alanna C; Bartz, Traci M; Fretts, Amanda M; Guo, Xiuqing; Lemaitre, Rozenn N; Liu, Ching-Ti; Noordam, Raymond; de Mutsert, Renée; Rosendaal, Frits R; Wang, Carol A; Beilin, Lawrence J; Mori, Trevor A; Oddy, Wendy H; Pennell, Craig E; Chai, Jin Fang; Whitton, Clare; van Dam, Rob M; Liu, Jianjun; Tai, E Shyong; Sim, Xueling; Neuhouser, Marian L; Kooperberg, Charles; Tinker, Lesley F; Franceschini, Nora; Huan, TianXiao; Winkler, Thomas W; Bentley, Amy R; Gauderman, W James; Heerkens, Luc; Tanaka, Toshiko; van Rooij, Jeroen; Munroe, Patricia B; Warren, Helen R; Voortman, Trudy; Chen, Honglei; Rao, D C; Levy, Daniel; Ma, Jiantao.
Affiliation
  • Guirette M; Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (M.G., J.L., J.M.).
  • Lan J; Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (M.G., J.L., J.M.).
  • McKeown NM; Programs of Nutrition, Department of Health Sciences, Sargent College of Health & Rehabilitation Sciences, Boston University, MA (N.M.M.).
  • Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (M.R.B., H.C., P.S.d.V., A.C.M.).
  • Chen H; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (M.R.B., H.C., P.S.d.V., A.C.M.).
  • de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (M.R.B., H.C., P.S.d.V., A.C.M.).
  • Kim H; Department of Epidemiology (H.K., A.M.F.), Cardiovascular Health Research Unit, University of Washington, Seattle, WA.
  • Rebholz CM; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (C.M.R.).
  • Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (M.R.B., H.C., P.S.d.V., A.C.M.).
  • Bartz TM; Departments of Biostatistics and Medicine (T.M.B.), Cardiovascular Health Research Unit, University of Washington, Seattle, WA.
  • Fretts AM; Department of Epidemiology (H.K., A.M.F.), Cardiovascular Health Research Unit, University of Washington, Seattle, WA.
  • Guo X; The Lundquist Institute at Harbor-University of California, Los Angeles, Torrance, CA (X.G.).
  • Lemaitre RN; Department of Medicine (R.N.L.), Cardiovascular Health Research Unit, University of Washington, Seattle, WA.
  • Liu CT; Biostatistics, Boston University School of Public Health, MA (C.-T.L.).
  • Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics (R.N.), Leiden University Medical Center, the Netherlands.
  • de Mutsert R; Department of Clinical Epidemiology (R.d.M., F.R.R.), Leiden University Medical Center, the Netherlands.
  • Rosendaal FR; Department of Clinical Epidemiology (R.d.M., F.R.R.), Leiden University Medical Center, the Netherlands.
  • Wang CA; School of Medicine and Public Health, University of Newcastle, NSW, Australia (C.A.W., C.E.P).
  • Beilin LJ; Mothers' and Babies' Research Program, Hunter Medical Research Institute, NSW, Australia (C.A.W., C.E.P.).
  • Mori TA; Medical School, Royal Perth Hospital Unit, University of Western Australia, Crawley (L.J.B., T.A.M.).
  • Oddy WH; Medical School, Royal Perth Hospital Unit, University of Western Australia, Crawley (L.J.B., T.A.M.).
  • Pennell CE; Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (W.H.O.).
  • Chai JF; School of Medicine and Public Health, University of Newcastle, NSW, Australia (C.A.W., C.E.P).
  • Whitton C; Mothers' and Babies' Research Program, Hunter Medical Research Institute, NSW, Australia (C.A.W., C.E.P.).
  • van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System (J.F.C., C.W., R.M.v.D., E.S.T., X.S.).
  • Liu J; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System (J.F.C., C.W., R.M.v.D., E.S.T., X.S.).
  • Tai ES; School of Population Health, Curtin University, Perth, Western Australia, Australia (C.W.).
  • Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System (J.F.C., C.W., R.M.v.D., E.S.T., X.S.).
  • Neuhouser ML; Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University (R.M.v.D.).
  • Kooperberg C; Genome Institute of Singapore, Agency for Science, Technology and Research (J.L.).
  • Tinker LF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System (J.F.C., C.W., R.M.v.D., E.S.T., X.S.).
  • Franceschini N; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore (E.S.T.).
  • Huan T; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System (J.F.C., C.W., R.M.v.D., E.S.T., X.S.).
  • Winkler TW; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA (M.L.N., C.K., L.F.T.).
  • Bentley AR; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA (M.L.N., C.K., L.F.T.).
  • Gauderman WJ; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA (M.L.N., C.K., L.F.T.).
  • Heerkens L; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill (N.F.).
  • Tanaka T; Framingham Heart Study and Population Sciences Branch, National Heart, Lung, and Blood Institute, MA (T.H., D.L.).
  • van Rooij J; Department of Genetic Epidemiology, University of Regensburg, Germany (T.W.W.).
  • Munroe PB; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD (A.R.B.).
  • Warren HR; Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California (W.J.G.).
  • Voortman T; Division of Human Nutrition and Health, Wageningen University & Research, the Netherlands (L.H.).
  • Chen H; Longitudinal Studies Section, National Institute on Aging, Baltimore, MD (T.T.).
  • Rao DC; Department of Internal Medicine (J.v.R.), Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Levy D; Centre of Clinical Pharmacology & Precision Medicine, William Harvey Research Institute, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London, United Kingdom (P.B.M., H.R.W.).
  • Ma J; Centre of Clinical Pharmacology & Precision Medicine, William Harvey Research Institute, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London, United Kingdom (P.B.M., H.R.W.).
Hypertension ; 81(3): 552-560, 2024 Mar.
Article de En | MEDLINE | ID: mdl-38226488
ABSTRACT

BACKGROUND:

The Dietary Approaches to Stop Hypertension (DASH) diet score lowers blood pressure (BP). We examined interactions between genotype and the DASH diet score in relation to systolic BP.

METHODS:

We analyzed up to 9 420 585 single nucleotide polymorphisms in up to 127 282 individuals of 6 population groups (91% of European population) from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (n=35 660) and UK Biobank (n=91 622) and performed European population-specific and cross-population meta-analyses.

RESULTS:

We identified 3 loci in European-specific analyses and an additional 4 loci in cross-population analyses at Pinteraction<5e-8. We observed a consistent interaction between rs117878928 at 15q25.1 (minor allele frequency, 0.03) and the DASH diet score (Pinteraction=4e-8; P for heterogeneity, 0.35) in European population, where the interaction effect size was 0.42±0.09 mm Hg (Pinteraction=9.4e-7) and 0.20±0.06 mm Hg (Pinteraction=0.001) in Cohorts for Heart and Aging Research in Genomic Epidemiology and the UK Biobank, respectively. The 1 Mb region surrounding rs117878928 was enriched with cis-expression quantitative trait loci (eQTL) variants (P=4e-273) and cis-DNA methylation quantitative trait loci variants (P=1e-300). Although the closest gene for rs117878928 is MTHFS, the highest narrow sense heritability accounted by single nucleotide polymorphisms potentially interacting with the DASH diet score in this locus was for gene ST20 at 15q25.1.

CONCLUSIONS:

We demonstrated gene-DASH diet score interaction effects on systolic BP in several loci. Studies with larger diverse populations are needed to validate our findings.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Régime DASH / Hypertension artérielle Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: Hypertension Année: 2024 Type de document: Article
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Régime DASH / Hypertension artérielle Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: Hypertension Année: 2024 Type de document: Article