Senolytic combination of dasatinib and quercetin protects against diabetic kidney disease by activating autophagy to alleviate podocyte dedifferentiation via the Notch pathway.

Zhu, Xinwang; Zhang, Congxiao; Liu, Linlin; Xu, Li; Yao, Li

Senolytic combination of dasatinib and quercetin protects against diabetic kidney disease by activating autophagy to alleviate podocyte dedifferentiation via the Notch pathway.

Zhu, Xinwang; Zhang, Congxiao; Liu, Linlin; Xu, Li; Yao, Li.

Affiliation

Zhu X; Department of Nephrology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Zhang C; Department of Nephrology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Liu L; Department of Nephrology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Xu L; Department of Laboratory Medicine, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524003, P.R. China.
Yao L; Department of Nephrology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.

Int J Mol Med ; 53(3)2024 03.

Article de En | MEDLINE | ID: mdl-38240118

Sujet(s)
Mots clés

Notch pathway; autophagy; dasatinib and quercetin; diabetic kidney disease; podocyte differentiation; senolytics

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Diabète / Néphropathies diabétiques / Podocytes Limites: Animals Langue: En Journal: Int J Mol Med Sujet du journal: BIOLOGIA MOLECULAR / GENETICA MEDICA Année: 2024 Type de document: Article Pays de publication: Grèce

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