Comparison between combination of tamsulosin and Pentoxifylline versus tamsulosin alone in the treatment of lower urinary tract symptoms due to benign prostate hyperplasia: A preliminary study.
Low Urin Tract Symptoms
; 16(1): e12509, 2024 Jan.
Article
de En
| MEDLINE
| ID: mdl-38282138
ABSTRACT
BACKGROUND:
In older adults, bladder outlet obstruction (BOO) is prevalent, primarily due to benign prostatic hyperplasia (BPH). These patients' lower urinary tract symptoms can be treated surgically and with medical therapy. Compared to standard treatment with tamsulosin, Pentoxifylline, a phosphodiesterase inhibitor, could benefit patients with BOO due to its properties on microcirculatory blood flow and oxygenation of ischemic tissues. Hence, this trial intended to study the efficacy of Pentoxifylline combined with tamsulosin in treating BOO patients. MATERIALS ANDMETHODS:
This randomized, double-blind clinical trial recruited 60 patients with BPH from a single center in 2022. Upon consent of patients meeting the eligibility criteria, they were randomly allocated to intervention (Pentoxifylline + tamsulosin) and control (placebo + tamsulosin) groups. The patients were evaluated for international prostate symptom score (IPSS), quality of life (QoL), maximum urinary flow rate (Qmax ) by uroflowmetry, and post-void residual volume (PVR) by abdominal sonography at the onset of the study and after the 12th week.RESULTS:
Patients who used the combination therapy had significantly better results of prostate symptoms and quality of life improvement (IPSS -36.6%, QoL -45.3%) compared to patients who received tamsulosin alone (IPSS -21.2%, QoL -27.7%) (p < .001). Also, this study shows that the improvement in maximum urinary flow rate and residual volume by combination therapy is significantly higher (Qmax +42.5%, PVR -42.6%) compared to monotherapy (Qmax +25.1%, PVR -26.1%) (p < .001).CONCLUSION:
When combined with tamsulosin, Pentoxifylline could significantly improve the lower urinary symptoms of BPH patients. It is well tolerated, and the treatment outcomes are better in patients who receive the combination of Pentoxifylline and tamsulosin than those who only receive tamsulosin.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pentoxifylline
/
Hyperplasie de la prostate
/
Obstruction du col de la vessie
/
Symptômes de l'appareil urinaire inférieur
Type d'étude:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
Aspects:
Patient_preference
Limites:
Aged
/
Humans
/
Male
Langue:
En
Journal:
Low Urin Tract Symptoms
Année:
2024
Type de document:
Article
Pays d'affiliation:
Iran