Green micellar liquid chromatographic method for simultaneous determination of antihistaminic drugs tripelennamine hydrochloride and diphenhydramine in pharmaceutical gel.
J Sep Sci
; 47(2): e2300757, 2024 Jan.
Article
de En
| MEDLINE
| ID: mdl-38286731
ABSTRACT
A new green micellar liquid chromatographic method has been developed and validated for the simultaneous determination of diphenhydramine (DPH) and tripelennamine hydrochloride (TRP) using a micellar mobile phase consisting of 1 mM Tween 20 in phosphate buffer pH 4isopropanol (8515, %v/v). The method was linear in the range of 4-150 and 5-120 µg/mL for TRP and DPH, respectively. The method was successfully applied for the simultaneous determination of DPH and TRP in a laboratory-prepared gel containing all possible excipients with mean percent recoveries ± standard deviation of 100.346 ± 1.265 and 100.754 ± 1.117 for TRP and DPH, respectively. The method was validated according to the International Conference on Harmonization guidelines. The method is confirmed to have excellent greenness.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tripélennamine
/
Diphénhydramine
Langue:
En
Journal:
J Sep Sci
/
J. sep. sci
/
Journal of separation science
Année:
2024
Type de document:
Article
Pays d'affiliation:
Égypte
Pays de publication:
Allemagne