Genetic polymorphism of KIAA1217 is functionally associated with lumbar disc herniation in the Chinese population.
Neurochirurgie
; 70(2): 101538, 2024 Mar.
Article
de En
| MEDLINE
| ID: mdl-38311218
ABSTRACT
BACKGROUND:
Genetic polymorphism of KIAA1217 has been reported to be associated with lumbar disc herniation (LDH) in different populations such as Japanese population and Finnish population. This study aimed to explore whether the genetic polymorphism of KIAA1217 is functionally associated with LDH in Chinese population.METHODS:
SNP rs16924573 of KIAA1217 was genotyped in 1272 patients and 1248 healthy controls. The mRNA expression of KIAA1217 in the intervertebral disc was analyzed for 84 patients and 32 controls. The differences of genotype and allele distributions between LDH patients and healthy controls were evaluated using the Chi-square test. One-way ANOVA test was used to compare the relationship between genotypes and tissue expression of KIAA1217.RESULTS:
Patients were found to have significantly higher frequency of genotype GG of rs16924573 than the controls (64.2% vs. 52.8%, p<0.001). The frequency of allele G was remarkably higher in the patients than in the controls (79.8% vs. 73.2%, p<0.001), with an OR of 1.45 (95% confidential interval=1.27-1.66). Compared with the controls, LDH patients were observed to have significantly decreased expression of KIAA1217. Patients with genotype GG had remarkably lower mRNA expression of KIAA1217 than those with genotype AG or AA (p=0.01).CONCLUSIONS:
SNP rs16924573 of KIAA1217 could be functionally associated with LDH in the Chinese population. More in vivo and vitro experiments need to be carried out to further clarify the regulatory mechanism of functional variants in KIAA1217.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Dégénérescence de disque intervertébral
/
Déplacement de disque intervertébral
Type d'étude:
Risk_factors_studies
Limites:
Humans
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
Neuro-chir.
/
Neuro-chirurgie
/
Neurochirurgie
Année:
2024
Type de document:
Article
Pays de publication:
France