Alkaloids from Fritillaria przewalskii Bulbs and Their Anti-Alzheimer's Disease Activities.
Chem Biodivers
; 21(3): e202400017, 2024 Mar.
Article
de En
| MEDLINE
| ID: mdl-38321767
ABSTRACT
Three undescribed isosteroidal alkaloids, przewalskines A-C (1-3), as well as seven known alkaloids (4-10) were obtained from Fritillaria przewalskii bulbs. Their structures were deduced by extensive HRESIMS, 1D NMR, and 2D NMR analyses, and their bioactivities were evaluated involving the anti-inflammatory and inhibitory potencies on AChE, BChE, and Aß aggregation. Compound 4 revealed the potent effect on inhibiting Aß aggregation activity with IC50 value of 33.1â
µM, AChE activity with IC50 value of 6.9â
µM, and also showed NO release inhibitory acitivity with IC50 value of 32.6â
µM. These findings contribute new multi-.target anti-AD agents and embody the chemical diversity of F. przewalskii.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Fritillaria
/
Alcaloïdes
Langue:
En
Journal:
Chem Biodivers
/
Chem. biodivers. (Online)
/
Chemistry & biodiversity (Online)
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2024
Type de document:
Article
Pays de publication:
Suisse