A Cyclical Magneto-Responsive Massage Dressing for Wound Healing.
Small
; 20(28): e2400644, 2024 Jul.
Article
de En
| MEDLINE
| ID: mdl-38326079
ABSTRACT
Tissue development is mediated by a combination of mechanical and biological signals. Currently, there are many reports on biological signals regulating repair. However, insufficient attention is paid to the process of mechanical regulation, especially the active mechanical regulation in vivo, which has not been realized. Herein, a novel dynamically regulated repair system for both in vitro and in vivo applications is developed, which utilizes magnetic nanoparticles as non-contact actuators to activate hydrogels. The magnetic hydrogel can be periodically activated and deformed to different amplitudes by a dynamic magnetic system. An in vitro skin model is used to explore the impact of different dynamic stimuli on cellular mechano-transduction signal activation and cell differentiation. Specifically, the effect of mechanical stimulation on the phenotypic transition of fibroblasts to myofibroblasts is investigated. Furthermore, in vivo results verify that dynamic massage can simulate and enhance the traction effect in skin defects, thereby accelerating the wound healing process by promoting re-epithelialization and mediating dermal contraction.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Bandages
/
Cicatrisation de plaie
/
Massage
Limites:
Animals
/
Humans
Langue:
En
Journal:
Small
/
Small (Weinh., Internet)
/
Small (Weinheim. Internet)
Sujet du journal:
ENGENHARIA BIOMEDICA
Année:
2024
Type de document:
Article
Pays de publication:
Allemagne