B cell activation and autoantibody production in autoimmune diseases.
Best Pract Res Clin Rheumatol
; 38(2): 101936, 2024 05.
Article
de En
| MEDLINE
| ID: mdl-38326197
ABSTRACT
B cells are central players in the immune system, responsible for producing antibodies and modulating immune responses. This review explores the intricate relationship between aberrant B cell activation and the development of autoimmune diseases, emphasizing the essential role of B cells in these conditions. We also summarize B cell receptor signaling and Toll-like receptor signaling in B cell activation, as well as their association with autoimmune diseases, shedding light on the molecular mechanisms behind these associations. Additionally, we explore the clinical observations involving B cell activation and their significance in autoimmune disease management. Various clinical studies related to B cell-targeted therapies are also discussed, offering insights into potential avenues for improving treatment strategies. Overall, this review serves as a resource for researchers and clinicians in the field of immunology and autoimmune diseases, providing a general view of B cell signaling and its role in autoimmunity.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Autoanticorps
/
Maladies auto-immunes
/
Lymphocytes B
/
Activation des lymphocytes
Limites:
Humans
Langue:
En
Journal:
Best Pract Res Clin Rheumatol
Sujet du journal:
REUMATOLOGIA
Année:
2024
Type de document:
Article
Pays de publication:
Pays-Bas