Age-related variation in coagulation factors in non-valvular atrial fibrillation patients receiving direct oral anticoagulants.
Int J Hematol
; 119(4): 407-415, 2024 Apr.
Article
de En
| MEDLINE
| ID: mdl-38334914
ABSTRACT
Age is a significant risk factor for ischemic stroke. However, the influence of aging on coagulation parameters in non-valvular atrial fibrillation (NVAF) patients treated with direct oral anticoagulants (DOACs) remains unclear. A total of 775 samples were collected from 224 NVAF patients receiving apixaban, edoxaban or rivaroxaban. The samples were categorized into three age groups (i) ≤ 64 years, (ii) 65-74 years, and (iii) ≥ 75 years (apixaban N = 48, 108, 119; edoxaban N = 63, 68, 126; rivaroxaban N = 115, 90, 38, respectively). Coagulation parameters including fibrinogen (Fbg), factor II, factor V, factor VII, factor X, and D-dimer, were compared between the three age groups for each drug. The slopes in the correlation between drug concentrations and modified diluted prothrombin time (mdPT) were also assessed. Fbg and factor V increased with age, while factor II and factor X decreased. Factor VII and D-dimer showed no significant differences across age categories. The slope in response to drug concentrations was similar between the age groups. In NVAF patients treated with apixaban, edoxaban and rivaroxaban, some coagulation parameters exhibited age-related variation. However, the response of mdPT to drug concentration was consistent across age categories.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pyridines
/
Fibrillation auriculaire
/
Thiazoles
/
Accident vasculaire cérébral
Type d'étude:
Risk_factors_studies
Limites:
Humans
/
Middle aged
Langue:
En
Journal:
Int J Hematol
Sujet du journal:
HEMATOLOGIA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Japon
Pays de publication:
Japon