The association of weight loss from anti-obesity medications or bariatric surgery and apnea-hypopnea index in obstructive sleep apnea.
Obes Rev
; 25(4): e13697, 2024 Apr.
Article
de En
| MEDLINE
| ID: mdl-38342767
ABSTRACT
INTRODUCTION:
Weight loss is recommended for individuals with obstructive sleep apnea (OSA) and overweight or obesity, but there is limited evidence to guide the selection of weight management strategies for patients who do not lose sufficient weight with diet and lifestyle changes. We evaluated the relationship between weight loss caused by pharmacologic or surgical interventions and subsequent improvement in OSA by the apnea-hypopnea index (AHI).METHODS:
PubMed, Cochrane CENTRAL, and EMBASE were searched for randomized trials comparing pharmacologic or surgical obesity interventions to usual care, placebo, or no treatment in adults with OSA. The association between percentage weight loss and AHI change between randomization and last follow-up was evaluated using meta-regression. PROSPERO CRD42022378853.RESULTS:
Ten eligible trials (n = 854 patients) were included. Four (n = 211) assessed bariatric surgery, and 6 (n = 643) assessed pharmacologic interventions over a median follow-up of 13 months (interquartile range 6-26 months). The linear best estimate of the change in AHI is 0.45 events per hour (95% Confidence Interval 0.18 to 0.73 events per hour) for every 1% body weight lost.CONCLUSIONS:
Weight loss caused by medication or surgery caused a proportionate improvement of the AHI. Providers could consider extrapolating from this relationship when advising patients of the expected effects of other pharmacologic or surgical interventions without direct evidence in OSA.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Agents antiobésité
/
Syndrome d'apnées obstructives du sommeil
/
Chirurgie bariatrique
Type d'étude:
Clinical_trials
/
Risk_factors_studies
Limites:
Adult
/
Humans
Langue:
En
Journal:
Obes Rev
Sujet du journal:
METABOLISMO
Année:
2024
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique