Association of Sociodemographic Factors with Surgical Management of Hepatoblastoma and Hepatocellular Carcinoma in Children.
J Pediatr
; 269: 113963, 2024 Jun.
Article
de En
| MEDLINE
| ID: mdl-38369237
ABSTRACT
OBJECTIVE:
To evaluate for disparities in surgical care among US children with hepatoblastoma (HB) and hepatocellular carcinoma (HCC). STUDYDESIGN:
In this retrospective National Cancer Database study (2004-2015), children aged <18 years with HB or HCC were included. Multivariable mixed-effects logistic regression was used to evaluate the association of sociodemographic factors (age, sex, race and ethnicity, insurance status, income, proximity to treating hospital) with the odds of undergoing surgical treatment after adjusting for disease-related factors (tumor size, metastasis, comorbidities) and hospital-level effects. Subgroup analyses by tumor histology were performed.RESULTS:
A total of 811 children were included (HB 80.9%; HCC 19.1%), of which 610 (75.2%) underwent surgical treatment. Following adjustment, decreased odds of undergoing surgical treatment were associated with Black race (OR 0.46 vs White, 95% CI [95% CI] 0.26-0.80, P = .01), and having Medicaid (OR 0.58 vs private, 95% CI 0.38-0.88, P = .01) or no insurance (OR 0.33 vs private, 95% CI 0.13-0.80, P = .02). In children with HB, Black race was associated with decreased odds of undergoing surgical treatment (OR 0.47 vs White, 95% CI 0.25-0.89, P = .02). In children with HCC, Medicaid (OR 0.10 vs private, 95% CI 0.03-0.35, P < .001), or no insurance status (OR 0.10 vs private, 95% CI 0.01-0.83, P = .03) were associated with decreased odds of undergoing surgical treatment. Other than metastatic disease, no additional factors were associated with likelihood of surgical treatment in any group.CONCLUSIONS:
Black race and having Medicaid or no insurance are independently associated with decreased odds of surgical treatment in children with HB and HCC, respectively. These children may be less likely to undergo curative surgery for their liver cancer.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Hépatoblastome
/
Carcinome hépatocellulaire
/
Disparités d'accès aux soins
/
Tumeurs du foie
Limites:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Pays/Région comme sujet:
America do norte
Langue:
En
Journal:
J Pediatr
Année:
2024
Type de document:
Article
Pays d'affiliation:
Colombie