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A locus coeruleus to dorsal hippocampus pathway mediates cue-induced reinstatement of opioid self-administration in male and female rats.
Markovic, Tamara; Higginbotham, Jessica; Ruyle, Brian; Massaly, Nicolas; Yoon, Hye Jean; Kuo, Chao-Cheng; Kim, Jenny R; Yi, Jiwon; Garcia, Jeniffer J; Sze, Eric; Abt, Julian; Teich, Rachel H; Dearman, Joanna J; McCall, Jordan G; Morón, Jose A.
Affiliation
  • Markovic T; Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, USA.
  • Higginbotham J; Pain Center, Washington University in St Louis, St. Louis, MO, USA.
  • Ruyle B; School of Medicine, Washington University in St Louis, St. Louis, MO, USA.
  • Massaly N; Department of Neuroscience, Washington University in St. Louis, St. Louis, MO, USA.
  • Yoon HJ; Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, USA.
  • Kuo CC; Pain Center, Washington University in St Louis, St. Louis, MO, USA.
  • Kim JR; School of Medicine, Washington University in St Louis, St. Louis, MO, USA.
  • Yi J; Department of Neuroscience, Washington University in St. Louis, St. Louis, MO, USA.
  • Garcia JJ; Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, USA.
  • Sze E; Pain Center, Washington University in St Louis, St. Louis, MO, USA.
  • Abt J; School of Medicine, Washington University in St Louis, St. Louis, MO, USA.
  • Teich RH; Department of Neuroscience, Washington University in St. Louis, St. Louis, MO, USA.
  • Dearman JJ; Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, USA.
  • McCall JG; Pain Center, Washington University in St Louis, St. Louis, MO, USA.
  • Morón JA; School of Medicine, Washington University in St Louis, St. Louis, MO, USA.
Neuropsychopharmacology ; 49(6): 915-923, 2024 May.
Article de En | MEDLINE | ID: mdl-38374364
ABSTRACT
Opioid use disorder is a chronic relapsing disorder encompassing misuse, dependence, and addiction to opioid drugs. Long term maintenance of associations between the reinforcing effects of the drug and the cues associated with its intake are a leading cause of relapse. Indeed, exposure to the salient drug-associated cues can lead to drug cravings and drug seeking behavior. The dorsal hippocampus (dHPC) and locus coeruleus (LC) have emerged as important structures for linking the subjective rewarding effects of opioids with environmental cues. However, their role in cue-induced reinstatement of opioid use remains to be further elucidated. In this study, we showed that chemogenetic inhibition of excitatory dHPC neurons during re-exposure to drug-associated cues significantly attenuates cue-induced reinstatement of morphine-seeking behavior. In addition, the same manipulation reduced reinstatement of sucrose-seeking behavior but failed to alter memory recall in the object location task. Finally, intact activity of tyrosine hydroxylase (TH) LC-dHPCTh afferents is necessary to drive cue induced reinstatement of morphine-seeking as inhibition of this pathway blunts cue-induced drug-seeking behavior. Altogether, these studies show an important role of the dHPC and LC-dHPCTh pathway in mediating cue-induced reinstatement of opioid seeking.
Sujet(s)

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Locus ceruleus / Autoadministration / Signaux / Comportement de recherche de substances / Hippocampe Limites: Animals Langue: En Journal: Neuropsychopharmacology Sujet du journal: NEUROLOGIA / PSICOFARMACOLOGIA Année: 2024 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Locus ceruleus / Autoadministration / Signaux / Comportement de recherche de substances / Hippocampe Limites: Animals Langue: En Journal: Neuropsychopharmacology Sujet du journal: NEUROLOGIA / PSICOFARMACOLOGIA Année: 2024 Type de document: Article Pays d'affiliation: États-Unis d'Amérique
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