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Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia.
Lee, Chel Hee; Banoei, Mohammad M; Ansari, Mariam; Cheng, Matthew P; Lamontagne, Francois; Griesdale, Donald; Lasry, David E; Demir, Koray; Dhingra, Vinay; Tran, Karen C; Lee, Terry; Burns, Kevin; Sweet, David; Marshall, John; Slutsky, Arthur; Murthy, Srinivas; Singer, Joel; Patrick, David M; Lee, Todd C; Boyd, John H; Walley, Keith R; Fowler, Robert; Haljan, Greg; Vinh, Donald C; Mcgeer, Alison; Maslove, David; Mann, Puneet; Donohoe, Kathryn; Hernandez, Geraldine; Rocheleau, Genevieve; Trahtemberg, Uriel; Kumar, Anand; Lou, Ma; Dos Santos, Claudia; Baker, Andrew; Russell, James A; Winston, Brent W.
Affiliation
  • Lee CH; Department of Critical Care Medicine, University of Calgary, Alberta, Canada.
  • Banoei MM; Department of Critical Care Medicine, University of Calgary, Alberta, Canada.
  • Ansari M; Department of Critical Care Medicine, University of Calgary, Alberta, Canada.
  • Cheng MP; Divisions of Infectious Diseases & Medical Microbiology, McGill University Health Center, McGill's Interdisciplinary Initiative in Infection and Immunity, Montreal, PQ, Canada.
  • Lamontagne F; University of Sherbrooke, Sherbrooke, QC, Canada.
  • Griesdale D; Critical Care Medicine, Vancouver General Hospital and University of British Columbia, 2775 Laurel St, Vancouver, BC, V5Z 1M9, Canada.
  • Lasry DE; Divisions of Infectious Diseases & Medical Microbiology, McGill University Health Center, McGill's Interdisciplinary Initiative in Infection and Immunity, Montreal, PQ, Canada.
  • Demir K; Divisions of Infectious Diseases & Medical Microbiology, McGill University Health Center, McGill's Interdisciplinary Initiative in Infection and Immunity, Montreal, PQ, Canada.
  • Dhingra V; Critical Care Medicine, Vancouver General Hospital and University of British Columbia, 2775 Laurel St, Vancouver, BC, V5Z 1M9, Canada.
  • Tran KC; Division of General Internal Medicine, Vancouver General Hospital and University of British Columbia, 2775 Laurel St, Vancouver, BC, V5Z 1M9, Canada.
  • Lee T; Centre for Health Evaluation and Outcome Science (CHEOS), St. Paul's Hospital and University of British Columbia, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.
  • Burns K; Department of Medicine, Division of Nephrology, Ottawa Hospital Research Institute, and University of Ottawa, 1967 Riverside Dr., Rm. 535, Ottawa, ON, K1H 7W9, Canada.
  • Sweet D; Critical Care Medicine and Emergency Medicine, Vancouver General Hospital and University of British Columbia, 2775 Laurel St, Vancouver, BC, V5Z 1M9, Canada.
  • Marshall J; Department of Surgery, St. Michael's Hospital and University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada.
  • Slutsky A; Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
  • Murthy S; British Columbia Children's Hospital, University of British Columbia, 4500 Oak Street, Vancouver, BC, V6H 3N1, Canada.
  • Singer J; Centre for Health Evaluation and Outcome Science (CHEOS), St. Paul's Hospital and University of British Columbia, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.
  • Patrick DM; British Columbia Centre for Disease Control (BCCDC) and School of Population and Public Health, University of British Columbia, 655 West 12th Avenue, Vancouver, BC, V5Z 4R4, Canada.
  • Lee TC; Divisions of Infectious Diseases & Medical Microbiology, McGill University Health Center, McGill's Interdisciplinary Initiative in Infection and Immunity, Montreal, PQ, Canada.
  • Boyd JH; Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
  • Walley KR; Division of Critical Care Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
  • Fowler R; Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
  • Haljan G; Division of Critical Care Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
  • Vinh DC; Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
  • Mcgeer A; Department of Medicine and Critical Care Medicine, Surrey Memorial Hospital, 13750 96th Avenue, Surrey, BC, V3V 1Z2, Canada.
  • Maslove D; Divisions of Infectious Diseases & Medical Microbiology, McGill University Health Center, McGill's Interdisciplinary Initiative in Infection and Immunity, Montreal, PQ, Canada.
  • Mann P; Mt. Sinai Hospital and University of Toronto, 600 University Avenue, Toronto, ON, M5G 1X5, Canada.
  • Donohoe K; Department of Critical Care, Kingston General Hospital and Queen's University, 76 Stuart Street, Kingston, ON, K7L 2V7, Canada.
  • Hernandez G; Black Tusk, Vancouver, BC, Canada.
  • Rocheleau G; Black Tusk, Vancouver, BC, Canada.
  • Trahtemberg U; Black Tusk, Vancouver, BC, Canada.
  • Kumar A; Black Tusk, Vancouver, BC, Canada.
  • Lou M; Department of Critical Care, Galilee Medical Center, Nahariya, Israel.
  • Dos Santos C; Bar Ilan University, Ramat Gan, Israel.
  • Baker A; Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.
  • Russell JA; Departments of Medicine and Medical Microbiology, University of Manitoba, Winnipeg, Canada.
  • Winston BW; Departments of Medicine and Medical Microbiology, University of Manitoba, Winnipeg, Canada.
Crit Care ; 28(1): 63, 2024 02 27.
Article de En | MEDLINE | ID: mdl-38414082
ABSTRACT
RATIONALE Acute respiratory distress syndrome (ARDS) is a life-threatening critical care syndrome commonly associated with infections such as COVID-19, influenza, and bacterial pneumonia. Ongoing research aims to improve our understanding of ARDS, including its molecular mechanisms, individualized treatment options, and potential interventions to reduce inflammation and promote lung repair.

OBJECTIVE:

To map and compare metabolic phenotypes of different infectious causes of ARDS to better understand the metabolic pathways involved in the underlying pathogenesis.

METHODS:

We analyzed metabolic phenotypes of 3 ARDS cohorts caused by COVID-19, H1N1 influenza, and bacterial pneumonia compared to non-ARDS COVID-19-infected patients and ICU-ventilated controls. Targeted metabolomics was performed on plasma samples from a total of 150 patients using quantitative LC-MS/MS and DI-MS/MS analytical platforms.

RESULTS:

Distinct metabolic phenotypes were detected between different infectious causes of ARDS. There were metabolomics differences between ARDSs associated with COVID-19 and H1N1, which include metabolic pathways involving taurine and hypotaurine, pyruvate, TCA cycle metabolites, lysine, and glycerophospholipids. ARDSs associated with bacterial pneumonia and COVID-19 differed in the metabolism of D-glutamine and D-glutamate, arginine, proline, histidine, and pyruvate. The metabolic profile of COVID-19 ARDS (C19/A) patients admitted to the ICU differed from COVID-19 pneumonia (C19/P) patients who were not admitted to the ICU in metabolisms of phenylalanine, tryptophan, lysine, and tyrosine. Metabolomics analysis revealed significant differences between C19/A, H1N1/A, and PNA/A vs ICU-ventilated controls, reflecting potentially different disease mechanisms.

CONCLUSION:

Different metabolic phenotypes characterize ARDS associated with different viral and bacterial infections.
Sujet(s)
Mots clés

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: / Pneumopathie bactérienne / Grippe humaine / Sous-type H1N1 du virus de la grippe A / COVID-19 Limites: Humans Langue: En Journal: Crit Care Année: 2024 Type de document: Article Pays d'affiliation: Canada

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: / Pneumopathie bactérienne / Grippe humaine / Sous-type H1N1 du virus de la grippe A / COVID-19 Limites: Humans Langue: En Journal: Crit Care Année: 2024 Type de document: Article Pays d'affiliation: Canada