Changes in regional tissue oxygen saturation values during the first week of life in stable preterm infants.
J Perinat Med
; 52(4): 445-451, 2024 May 27.
Article
de En
| MEDLINE
| ID: mdl-38436066
ABSTRACT
OBJECTIVES:
Near infrared spectroscopy (NIRS) is a non-invasive method for monitoring regional tissue oxygen saturation (rSO2). The purpose of this study is to investigate the changes that occur in cerebral, splanchnic, and renal rSO2 and fractional tissue oxygen extraction (FTOE) in stable preterm infants in the first week of life.METHODS:
Prospective observational study of infants born 30-34 weeks gestation at NYU Langone Health between November 2017 and November 2018. Cerebral, renal, and splanchnic rSO2 were monitored from 12 to 72â¯h of life, and at seven days. Subjects were divided into gestational age (GA) cohorts. Average rSO2, splanchnic cerebral oxygen ratio (SCOR), FTOE, and regional intra-subject variability was calculated at each location at five different time intervals 0-12â¯h, 12-24â¯h, 24-48â¯h, 48-72â¯h, and one week of life.RESULTS:
Twenty subjects were enrolled. The average cerebral rSO2 ranged from 76.8 to 92.8â¯%, renal rSO2 from 65.1 to 91.1â¯%, and splanchnic rSO2 from 36.1 to 76.3â¯%. The SCOR ranged from 0.45 to 0.94. The strongest correlation between the GA cohorts was in the cerebral region (R2=0.94) and weakest correlation was in the splanchnic region (R2=0.81). The FTOE increased in all three locations over time. Intra-subject variability was lowest in the cerebral region (1.3â¯% (±1.9)).CONCLUSIONS:
The cerebral region showed the strongest correlation between GA cohorts and lowest intra-subject variability, making it the most suitable for clinical use when monitoring for tissue hypoxia. Further studies are needed to further examine rSO2 in preterm infants.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Prématuré
/
Spectroscopie proche infrarouge
/
Saturation en oxygène
Limites:
Female
/
Humans
/
Male
/
Newborn
Langue:
En
Journal:
J Perinat Med
/
J. perinat. med
/
Journal of perinatal medicine
Année:
2024
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique
Pays de publication:
Allemagne