The role of long-lived plasma cells in viral clearance.
J Biol Dyn
; 18(1): 2325523, 2024 Dec.
Article
de En
| MEDLINE
| ID: mdl-38445631
ABSTRACT
The adaptive immune system has two types of plasma cells (PC), long-lived plasma cells (LLPC) and short-lived plasma cells (SLPC), that differ in their lifespan. In this paper, we propose that LLPC is crucial to the clearance of viral particles in addition to reducing the viral basic reproduction number in secondary infections. We use a sequence of within-host mathematical models to show that, CD8 T cells, SLPC and memory B cells cannot achieve full viral clearance, and the viral load will reach a low positive equilibrium level because of a continuous replenishment of target cells. However, the presence of LLPC is crucial for viral clearance.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Plasmocytes
/
Co-infection
Limites:
Humans
Langue:
En
Journal:
J Biol Dyn
Sujet du journal:
BIOLOGIA
Année:
2024
Type de document:
Article