In vitro Evaluation of the Antileishmanial and Antischistosomal Activities of p-Coumaric Acid Prenylated Derivatives.
Chem Biodivers
; 21(5): e202400491, 2024 May.
Article
de En
| MEDLINE
| ID: mdl-38470945
ABSTRACT
We have evaluated eight p-coumaric acid prenylated derivatives inâ
vitro for their antileishmanial activity against Leishmania amazonensis promastigotes and their antischistosomal activity against Schistosoma mansoni adult worms. Compound 7 ((E)-3,4-diprenyl-4-isoprenyloxycinnamic alcohol) was the most active against L. amazonensis (IC50=45.92â
µM) and S. mansoni (IC50=64.25â
µM). Data indicated that the number of prenyl groups, the presence of hydroxyl at C9, and a single bond between C7 and C8 are important structural features for the antileishmanial activity of p-coumaric acid prenylated derivatives.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Schistosoma mansoni
/
Acides coumariques
/
Tests de sensibilité parasitaire
/
Leishmania
/
Antiprotozoaires
Limites:
Animals
Langue:
En
Journal:
Chem Biodivers
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Brésil