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The role of vitamin D receptor in predentin mineralization and dental repair after injury.
Liu, Yudong; Wu, Yinlin; Hu, Xiaodong; Sun, Yu; Zeng, Guojin; Wang, Qinglong; Liu, Shanshan; Sun, Meiqun.
Affiliation
  • Liu Y; Department of Histology and Embryology, Bengbu Medical College, 2600 Dong Hai Avenue, Bengbu, 233030, China.
  • Wu Y; Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, 2600 Dong Hai Avenue, Bengbu, 233030, China.
  • Hu X; Bengbu Medical College, 2600 Dong Hai Avenue, Bengbu, 233030, China.
  • Sun Y; Department of Histology and Embryology, Bengbu Medical College, 2600 Dong Hai Avenue, Bengbu, 233030, China.
  • Zeng G; Department of Biochemistry and Molecular Biology, Bengbu Medical College, 2600 Dong Hai Avenue, Bengbu, 233030, China.
  • Wang Q; Bengbu Medical College, 2600 Dong Hai Avenue, Bengbu, 233030, China.
  • Liu S; Bengbu Medical College, 2600 Dong Hai Avenue, Bengbu, 233030, China.
  • Sun M; Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, 2600 Dong Hai Avenue, Bengbu, 233030, China. liushanshancan@163.com.
Cell Tissue Res ; 396(3): 343-351, 2024 Jun.
Article de En | MEDLINE | ID: mdl-38492000
ABSTRACT
Dentin is a permeable and complex tubular composite formed by the mineralization of predentin that mineralization and repair are of considerable clinical interest during dentin homeostasis. The role of Vdr, a receptor of vitamin D, in dentin homeostasis remains unexplored. The aim of the present study was to assess the impact of Vdr on predentin mineralization and dental repair. Vdr-knockout (Vdr-/-) mice models were constructed; histology and immunohistochemistry analyses were conducted for both WT and Vdr-/- mice. The finding revealed a thicker predentin in Vdr-/- mice, characterized by higher expression of biglycan and decorin. A dental injury model was employed to observe tertiary dentin formation in Vdr-/- mice with dental injuries. Results showed that tertiary dentin was harder to form in Vdr-/- mice with dental injury. Over time, heightened pulp invasion was observed at the injury site in Vdr-/- mice. Expression of biglycan and decorin was reduced in the predentin at the injury site in the Vdr-/- mice by immunohistochemistry. Taken together, our results imply that Vdr plays a regulatory role in predentin mineralization and tertiary dentin formation during dentin homeostasis.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Récepteur calcitriol / Souris knockout / Dentine Limites: Animals Langue: En Journal: Cell Tissue Res Année: 2024 Type de document: Article Pays d'affiliation: Chine Pays de publication: Allemagne

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Récepteur calcitriol / Souris knockout / Dentine Limites: Animals Langue: En Journal: Cell Tissue Res Année: 2024 Type de document: Article Pays d'affiliation: Chine Pays de publication: Allemagne