Corynebacterium bacteremia in patients with hematologic disorders: a case series and systematic literature review.
Leuk Lymphoma
; 65(7): 997-1002, 2024 Jul.
Article
de En
| MEDLINE
| ID: mdl-38498769
ABSTRACT
Corynebacterium is generally considered a contaminant in clinical practice. However, it may cause bacteremia in patients with hematologic disorders, and factors that contribute to its mortality are unclear. A case series and systematic literature review identified 96 cases of Corynebacterium bacteremia inhematologic disorderpatients. The median age was 50.5 years (range 2-93 years), with 79 (82%) patients 18 years or older, and 64 (67%) patients male. Most cases involved hematologic malignancies, and neutropenia was observed in approximately 75% cases. The most common sites of infection/symptoms were skin and soft tissue, respiratory, and catheter-related bloodstream infection. The infection-related mortality was 23%, and univariate analysis showed that age, respiratory infection/symptoms, and source control were significantly associated with infection-related mortality. Multivariate analysis indicates that infection-related mortality was significantly reduced by source control (OR 0.24, 95% CI 0.06-0.97, p = 0.046). Therefore, when Corynebacterium infections are suspected, early source control should be considered.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Bactériémie
/
Corynebacterium
/
Infections à Corynebacterium
/
Hémopathies
Limites:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Leuk Lymphoma
/
Leuk. lymphoma
/
Leukemia and lymphoma
Sujet du journal:
HEMATOLOGIA
/
NEOPLASIAS
Année:
2024
Type de document:
Article
Pays d'affiliation:
Japon
Pays de publication:
États-Unis d'Amérique