Restless legs syndrome in patients with obstructive sleep apnea: Association between apnea severity and symptoms of depression, insomnia, and daytime sleepiness.
Sleep Med
; 117: 40-45, 2024 May.
Article
de En
| MEDLINE
| ID: mdl-38507975
ABSTRACT
OBJECTIVE:
To determine if the prevalence and severity of restless legs syndrome (RLS) varies with apnea severity and analyze differences between the sexes in terms of comorbid RLS with symptoms of depression, insomnia, and daytime sleepiness in patients with obstructive sleep apnea (OSA).METHODS:
Symptoms of depression, insomnia, and daytime sleepiness were defined as Patient Health Questionnaire-9 score ≥10, Insomnia Severity Index score ≥15, and Epworth Sleepiness Scale score ≥11. Multivariate logistic and linear regression analyses were conducted.RESULTS:
In 707 adults with OSA (85.1% males), 16.1% (n = 114) had comorbid RLS. The prevalence of RLS was markedly lower in those with moderate and severe OSA than in those with mild OSA. Similarly, the odds of RLS significantly decreased with increasing apnea-hypopnea index. After controlling for age and sex, in patients with comorbid RLS, the International RLS Study Group Rating Scale scores were negatively correlated with apnea-hypopnea index and a nadir peripheral oxygen saturation during sleep. The presence of RLS was more likely to be associated with symptoms of depression, insomnia, and daytime sleepiness after controlling for confounding variables, but only in men.CONCLUSIONS:
RLS is frequently noted in combination with OSA, with a female preponderance. The severities of OSA and RLS may be negatively associated. In patients with OSA, sex-related differences in terms of comorbid RLS with symptoms of depression, insomnia, and daytime sleepiness warrant further investigations.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Syndrome des jambes sans repos
/
Syndrome d'apnées obstructives du sommeil
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Troubles du sommeil par somnolence excessive
/
Troubles de l'endormissement et du maintien du sommeil
Limites:
Adult
/
Female
/
Humans
/
Male
Langue:
En
Journal:
Sleep Med
Sujet du journal:
NEUROLOGIA
/
PSICOFISIOLOGIA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Corée du Sud