Immunotherapy and Radiotherapy Combinations for Sarcoma.
Semin Radiat Oncol
; 34(2): 229-242, 2024 Apr.
Article
de En
| MEDLINE
| ID: mdl-38508787
ABSTRACT
Sarcomas are a heterogeneous group of bone and soft tissue tumors. Survival outcomes for advanced (unresectable or metastatic) disease remain poor, so therapeutic improvements are needed. Radiotherapy plays an integral role in the neoadjuvant and adjuvant treatment of localized disease as well as in the treatment of metastatic disease. Combining radiotherapy with immunotherapy to potentiate immunotherapy has been used in a variety of cancers other than sarcoma, and there is opportunity to further investigate combining immunotherapy with radiotherapy to try to improve outcomes in sarcoma. In this review, we describe the diversity of the tumor immune microenvironments for sarcomas and describe the immunomodulatory effects of radiotherapy. We discuss studies on the timing of radiotherapy relative to immunotherapy and studies on the radiotherapy dose and fractionation regimen to be used in combination with immunotherapy. We describe the impact of radiotherapy on the tumor immune microenvironment. We review completed and ongoing clinical trials combining radiotherapy with immunotherapy for sarcoma and propose future directions for studies combining immunotherapy with radiotherapy in the treatment of sarcoma.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Sarcomes
/
Tumeurs des tissus mous
Limites:
Humans
Langue:
En
Journal:
Semin Radiat Oncol
/
Semin. radiat. oncol
/
Seminars in radiation oncology
Sujet du journal:
NEOPLASIAS
/
RADIOLOGIA
Année:
2024
Type de document:
Article
Pays de publication:
États-Unis d'Amérique