How the Brain Develops from the Epiblast: The Node Is Not an Organizer.
Results Probl Cell Differ
; 72: 61-80, 2024.
Article
de En
| MEDLINE
| ID: mdl-38509252
ABSTRACT
Studies using early-stage avian embryos have substantially impacted developmental biology, through the availability of simple culture methods and easiness in tissue manipulation. However, the regulations underlying brain and head development, a central issue of developmental biology, have not been investigated systematically. Yoshihi et al. (2022a) devised a technique to randomly label the epiblast cells with a green fluorescent protein before their development into the brain tissue. This technique was combined with grafting a node or node-derived anterior mesendoderm labeled with a cherry-colored fluorescent protein. Then cellular events were live-recorded over 18 hours during the brain and head development. The live imaging-based analyses identified previously undescribed mechanisms central to brain development all anterior epiblast cells have a potential to develop into the brain tissues and their gathering onto a proximal anterior mesendoderm forms a brain primordium whereas the remaining cells develop into the covering head ectoderm. The analyses also ruled out the direct participation of the node's activity in the brain development. Yoshihi et al. (2022a) also demonstrate how the enigmatic data from classical models can be reinterpreted in the new model.This chapter was adapted from Yoshihi K, Iida H, Teramoto M, Ishii Y, Kato K, Kondoh H. (2022b). Epiblast cells gather onto the anterior mesendoderm and initiate brain development without the direct involvement of the node in avian embryos Insights from broad-field live imaging. Front Cell Dev Biol. 101019845. doi 10.3389/fcell.2022.1019845.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Gastrula
/
Feuillets embryonnaires
Langue:
En
Journal:
Results Probl Cell Differ
Année:
2024
Type de document:
Article
Pays d'affiliation:
Japon
Pays de publication:
Allemagne