PyrAtes: Modular Organic Salts with Large Stokes Shifts for Fluo-rescence Microscopy.
Angew Chem Int Ed Engl
; 63(19): e202318127, 2024 05 06.
Article
de En
| MEDLINE
| ID: mdl-38570814
ABSTRACT
The deployment of small-molecule fluorescent agents plays an ever-growing role in medicine and drug development. Herein, we complement the portfolio of powerful fluorophores, reporting the serendipitous discovery and development of a novel class with an imidazo[1,2-a]pyridinium triflate core, which we term PyrAtes. These fluorophores are synthesized in a single step from readily available materials (>60â
examples) and display Stokes shifts as large as 240â
nm, while also reaching NIR-I emissions at λmax as long as 720â
nm. Computational studies allow the development of a platform for the prediction of λmax and λEm. Furthermore, we demonstrate the compatibility of these novel fluorophores with live cell imaging in HEK293 cells, suggesting PyrAtes as potent intracellular markers.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Colorants fluorescents
Limites:
Humans
Langue:
En
Journal:
Angew Chem Int Ed Engl
Année:
2024
Type de document:
Article
Pays d'affiliation:
Autriche
Pays de publication:
Allemagne