Severe DRESS with myocarditis secondary to naproxen/esomeprazole.
BMJ Case Rep
; 17(4)2024 Apr 09.
Article
de En
| MEDLINE
| ID: mdl-38594198
ABSTRACT
A man in his 60s presented with a widespread erythematous rash and associated chills, paraesthesia and haematuria. He had recently commenced naproxen/esomeprazole. Blood tests showed hypereosinophilia (0.73×109/L) and moderate acute kidney injury. Histology revealed parakeratosis, mild spongiosis with eosinophils. He developed acute coronary syndrome with rapid atrial fibrillation. Coronary angiogram was non-obstructive. Cardiac MRI (CMR) revealed acute myocarditis secondary to Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). Naproxen/esomeprazole was discontinued, and he was supported with oral corticosteroids. A repeat CMR 3 months later showed resolution of myocarditis. Naproxen/esomeprazole is not a common offending drug. DRESS is a rare drug-induced hypersensitivity reaction with a mortality rate of 10%. The objective of this case report is to highlight the significant but rare cardiac complications that can ensue from DRESS, which warrant prompt recognition and withdrawal of the causative drug.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Éosinophilie
/
Syndrome d'hypersensibilité médicamenteuse
/
Myocardite
Limites:
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
BMJ Case Rep
Année:
2024
Type de document:
Article
Pays d'affiliation:
Irlande