Association Between Liver Fibrosis Score and Diabetic Kidney Disease: A Retrospective Cross-Sectional Study of Hospitalized Patients.
Exp Clin Endocrinol Diabetes
; 132(6): 328-335, 2024 Jun.
Article
de En
| MEDLINE
| ID: mdl-38599609
ABSTRACT
OBJECTIVES:
To investigate the association between liver fibrosis score and diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM).METHODS:
A total of 897 hospitalized patients with T2DM were included in this study. Each patient completed DKD screening. Logistic regression analysis was used to assess the predictive value of non-alcoholic fatty liver disease fibrosis score (NAFLD-FS) and fibrosis-4 (FIB-4) for the occurrence of DKD and risk for DKD progression, respectively.RESULTS:
The prevalence of DKD and risk for its progression significantly increased with increasing NAFLD-FS risk category. DKD prevalence also increased with increasing FIB-4 risk category. Multivariate logistic regression analysis showed that the "high-risk" NAFLD-FS had a significantly higher risk of DKD (odds ratio [OR] 1.89, 95% confidence interval [CI] 1.16-3.08) and risk for DKD progression (OR 2.88, 95% CI 1.23-6.78), and the "intermediate-risk" FIB-4 had a significantly higher risk of DKD (OR 1.41, 95% CI 1.00-1.98). Subgroup analysis showed that the association between NAFLD-FS and FIB-4 and DKD was significant in the female subgroup, whereas the association between the "high-risk" NAFLD-FS and risk for DKD progression was significant in the male subgroup.CONCLUSIONS:
NAFLD-FS and FIB-4 are strongly associated with DKD and risk for DKD progression in patients with T2DM. Additionally, sexual dimorphism exists in this association.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Diabète de type 2
/
Néphropathies diabétiques
/
Cirrhose du foie
Limites:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Exp Clin Endocrinol Diabetes
Sujet du journal:
ENDOCRINOLOGIA
Année:
2024
Type de document:
Article
Pays de publication:
Allemagne