Pd-catalyzed stereoselective synthesis of chromone C-glycosides.
Chem Commun (Camb)
; 60(36): 4838-4841, 2024 Apr 30.
Article
de En
| MEDLINE
| ID: mdl-38619439
ABSTRACT
Herein, we present an efficient Pd-catalysed method for stereoselective synthesis of chromone C-glycosides from various glycals. We successfully applied this method to various glycals with different protecting groups, yielding the corresponding glycosides in 41-78% yields. Additionally, we investigated the potential of this approach for the late-stage modification of natural products and pharmaceutical compounds linked to glycals, leading to the synthesis of their respective glycosides. Furthermore, we extended our research to gram-scale synthesis and demonstrated its applicability in producing various valuable products, including 2-deoxy-chromone C-glycosides. In summary, our work introduces a novel library of chromone glycosides, which holds promise for advancing drug discovery efforts.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Palladium
/
4H-1-Benzopyran-4-ones
/
Hétérosides
Langue:
En
Journal:
Chem Commun (Camb)
/
Chem. commun. (Lond., 1996, Online)
/
Chemical communications (London. 1996. Online)
Sujet du journal:
QUIMICA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Inde
Pays de publication:
Royaume-Uni