Lipoic acid attachment to proteins: stimulating new developments.
Microbiol Mol Biol Rev
; 88(2): e0000524, 2024 Jun 27.
Article
de En
| MEDLINE
| ID: mdl-38624243
ABSTRACT
SUMMARYLipoic acid-modified proteins are essential for central metabolism and pathogenesis. In recent years, the Escherichia coli and Bacillus subtilis lipoyl assembly pathways have been modified and extended to archaea and diverse eukaryotes including humans. These extensions include a new pathway to insert the key sulfur atoms of lipoate, several new pathways of lipoate salvage, and a novel use of lipoic acid in sulfur-oxidizing bacteria. Other advances are the modification of E. coli LplA for studies of protein localization and protein-protein interactions in cell biology and in enzymatic removal of lipoate from lipoyl proteins. Finally, scenarios have been put forth for the evolution of lipoate assembly in archaea.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Bacillus subtilis
/
Acide lipoïque
/
Escherichia coli
Limites:
Humans
Langue:
En
Journal:
Microbiol Mol Biol Rev
Sujet du journal:
BIOLOGIA MOLECULAR
/
MICROBIOLOGIA
Année:
2024
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique
Pays de publication:
États-Unis d'Amérique