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Inhibition of superoxide and iNOS augment cutaneous nitric oxide-dependent vasodilation in non-Hispanic black young adults.
Wong, Brett J; Turner, Casey G; Hayat, Matthew J; Otis, Jeffrey S; Quyyumi, Arshed A.
Affiliation
  • Wong BJ; Department of Kinesiology & Health, Georgia State University, Atlanta, Georgia, USA.
  • Turner CG; Department of Kinesiology & Health, Georgia State University, Atlanta, Georgia, USA.
  • Hayat MJ; Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA.
  • Otis JS; Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, Georgia, USA.
  • Quyyumi AA; Department of Kinesiology & Health, Georgia State University, Atlanta, Georgia, USA.
Physiol Rep ; 12(8): e16021, 2024 Apr.
Article de En | MEDLINE | ID: mdl-38639714
ABSTRACT
We assessed the combined effect of superoxide and iNOS inhibition on microvascular function in non-Hispanic Black and non-Hispanic White participants (n = 15 per group). Participants were instrumented with four microdialysis fibers (1) lactated Ringer's (control), (2) 10 µM tempol (superoxide inhibition), (3) 0.1 mM 1400 W (iNOS inhibition), (4) tempol + 1400 W. Cutaneous vasodilation was induced via local heating and NO-dependent vasodilation was quantified. At control sites, NO-dependent vasodilation was lower in non-Hispanic Black (45 ± 9% NO) relative to non-Hispanic White (79 ± 9% NO; p < 0.01; effect size, d = 3.78) participants. Tempol (62 ± 16% NO), 1400 W (78 ± 12% NO) and tempol +1400 W (80 ± 13% NO) increased NO-dependent vasodilation in non-Hispanic Black participants relative to control sites (all p < 0.01; d = 1.22, 3.05, 3.03, respectively). The effect of 1400 W (p = 0.04, d = 1.11) and tempol +1400 W (p = 0.03, d = 1.22) was greater than tempol in non-Hispanic Black participants. There was no difference between non-Hispanic Black and non-Hispanic White participants at 1400 W or tempol + 1400 W sites. These data suggest iNOS has a greater effect on NO-dependent vasodilation than superoxide in non-Hispanic Black participants.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Marqueurs de spin / Vasodilatation / N-oxydes cycliques / Imines / Monoxyde d&apos;azote Limites: Adult / Humans Langue: En Journal: Physiol Rep Année: 2024 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Marqueurs de spin / Vasodilatation / N-oxydes cycliques / Imines / Monoxyde d&apos;azote Limites: Adult / Humans Langue: En Journal: Physiol Rep Année: 2024 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique