Circulating serotypes and genotypes of dengue virus in North India: An observational study.
J Vector Borne Dis
; 61(1): 117-122, 2024 Jan 01.
Article
de En
| MEDLINE
| ID: mdl-38648413
ABSTRACT
BACKGROUND OBJECTIVES:
This study reports observation on circulating serotypes and genotypes of Dengue Virus in North India.METHODS:
Serum samples were obtained from suspected cases of dengue referred to the virus diagnostic laboratory during 2014 to 2022. All samples were tested for anti-dengue virus IgM antibodies and NS1Ag by ELISA. NS1Ag positive samples were processed for serotyping and genotyping.RESULTS:
Total 41,476 dengue suspected cases were referred to the laboratory of which 12,292 (29.6%) tested positive. Anti-Dengue Virus IgM antibodies, NS1Ag, both IgM and NS1Ag, were positive in 7007 (57.4%); 3200 (26.0%) and 2085 (16.0%) cases respectively. Total 762 strains were serotyped during 9-year period. DENV-1, DENV-2, DENV-3 and DENV-4 serotypes were found in 79 (10.37%), 506 (66.40%), 151 (19.82%) and 26 (3.41%) cases respectively. DENV-1, DENV-2 and DENV-3 were in circulation throughout. Total 105 strains were genotyped. Genotype IV of DENV-1 serotype was circulating till 2014 which was later replaced by genotype V. A distinct seasonality with increase in number of cases in post-monsoon period was seen. INTERPRETATIONCONCLUSION:
DENV-1, DENV-2 and DENV-3 were found to be in circulation in North India. Predominant serotype/genotype changed at times, but not at regular intervals.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Dengue
/
Virus de la dengue
/
Sérogroupe
/
Génotype
/
Anticorps antiviraux
Limites:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
/
Middle aged
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
J Vector Borne Dis
Sujet du journal:
MEDICINA TROPICAL
/
PARASITOLOGIA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Inde