Clinical, pathologic and molecular findings in 2 Rottweiler littermates with appendicular osteosarcoma.
Res Sq
; 2024 Apr 11.
Article
de En
| MEDLINE
| ID: mdl-38659878
ABSTRACT
Appendicular osteosarcoma was diagnosed and treated in a pair of littermate Rottweiler dogs, resulting in distinctly different clinical outcomes despite similar therapy within the context of a prospective, randomized clinical trial (NCI-COTC021/022). Histopathology, immunohistochemistry, mRNA sequencing, and targeted DNA hotspot sequencing techniques were applied to both dogs' tumors to define factors that could underpin their differential response to treatment. We describe the comparison of their clinical, histologic and molecular features, as well as those from a companion cohort of Rottweiler dogs, providing new insight into potential prognostic biomarkers for canine osteosarcoma.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Langue:
En
Journal:
Res Sq
Année:
2024
Type de document:
Article
Pays de publication:
États-Unis d'Amérique