Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver.
Science
; 384(6694): 438-446, 2024 Apr 26.
Article
de En
| MEDLINE
| ID: mdl-38662831
ABSTRACT
Liver mitochondria play a central role in metabolic adaptations to changing nutritional states, yet their dynamic regulation upon anticipated changes in nutrient availability has remained unaddressed. Here, we found that sensory food perception rapidly induced mitochondrial fragmentation in the liver through protein kinase B/AKT (AKT)-dependent phosphorylation of serine 131 of the mitochondrial fission factor (MFFS131). This response was mediated by activation of hypothalamic pro-opiomelanocortin (POMC)-expressing neurons. A nonphosphorylatable MFFS131G knock-in mutation abrogated AKT-induced mitochondrial fragmentation in vitro. In vivo, MFFS131G knock-in mice displayed altered liver mitochondrial dynamics and impaired insulin-stimulated suppression of hepatic glucose production. Thus, rapid activation of a hypothalamus-liver axis can adapt mitochondrial function to anticipated changes of nutritional state in control of hepatic glucose metabolism.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Perception
/
Mitochondries du foie
/
Protéines mitochondriales
/
Dynamique mitochondriale
/
Aliments
/
Néoglucogenèse
/
Glucose
/
Foie
/
Protéines membranaires
Limites:
Animals
Langue:
En
Journal:
Science
Année:
2024
Type de document:
Article
Pays d'affiliation:
Allemagne