Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression.
Biomolecules
; 14(4)2024 Mar 27.
Article
de En
| MEDLINE
| ID: mdl-38672422
ABSTRACT
Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirrhosis. Multiple factors contribute to ALD progression and disease severity. Here, we overview several crucial mechanisms related to ALD end-stage outcome development, such as epigenetic changes, cell death, hemolysis, hepatic stellate cells activation, and hepatic fatty acid binding protein 4. Additionally, in this review, we also present two clinically relevant models using human precision-cut liver slices and hepatic organoids to examine ALD pathogenesis and progression.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Évolution de la maladie
/
Maladies alcooliques du foie
Limites:
Animals
/
Humans
Langue:
En
Journal:
Biomolecules
Année:
2024
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique