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The effect of compliance with PAP therapy on biochemical parameters in patients with obstructive sleep apnea syndrome: A 6-month follow-up study.
Aksakal, Alperen; Kerget, Bugra; Özkan, Hatice Beyza; Araz, Ömer; Yilmazel Uçar, Elif; Saglam, Leyla; Laloglu, Esra.
Affiliation
  • Aksakal A; Department of Pulmonary Diseases, Atatürk University Faculty of Medicine, Erzurum, Türkiye.
  • Kerget B; Department of Pulmonary Diseases, Atatürk University Faculty of Medicine, Erzurum, Türkiye.
  • Özkan HB; Department of Pulmonary Diseases, Atatürk University Faculty of Medicine, Erzurum, Türkiye.
  • Araz Ö; Department of Pulmonary Diseases, Atatürk University Faculty of Medicine, Erzurum, Türkiye.
  • Yilmazel Uçar E; Department of Pulmonary Diseases, Atatürk University Faculty of Medicine, Erzurum, Türkiye.
  • Saglam L; Department of Pulmonary Diseases, Atatürk University Faculty of Medicine, Erzurum, Türkiye.
  • Laloglu E; Department of Biochemistry, Atatürk University Faculty of Medicine, Erzurum, Türkiye.
Tuberk Toraks ; 72(1): 48-58, 2024 Mar.
Article de En | MEDLINE | ID: mdl-38676594
ABSTRACT

Introduction:

The gold standard treatment for obstructive sleep apnea syndrome (OSAS) is positive airway pressure therapy (PAP) treatments. PAP treatments reduce complications by reducing apnea and hypopnea attacks by creating airflow at a determined pressure. In our study, we aimed to examine the effect of treatment compliance on kidney and liver functions, apneahypopnea (AHI) index, and lipid profile of patients diagnosed with OSAS and started PAP treatment. Materials and

Methods:

Patients who were admitted to the sleep laboratory of our hospital between September 2022 and September 2023 and started PAP treatment after PSG were included in our study. Patients who were called for follow-up six months after the initiation of PAP treatment were divided into two groups according to their compliance with PAP treatment. Patients who used the device for at least four hours per night and more than 70% at night were grouped as PAP-compliant patients, while the other patients were grouped as non-PAP-compliant patients.

Result:

It was observed that uric acid, BUN, triglyceride, total cholesterol, ALT, GGT, ALP, and AHI levels of the patients who started PAP treatment decreased after six months (p= 0.001, 0.006, <0.001, 0.006, 0.01, <0.001, <0.001, <0.001 with). It was observed that HDL cholesterol levels increased (p≤ 0.001). It was observed that the change in uric acid, AHI, total cholesterol, and GGT levels in group 1 (n= 36) patients who were compliant with PAP treatment was statistically higher than in group 2 (n= 30) patients (p< 0.001, <0.03, <0.001, 0.008, respectively).

Conclusions:

Uric acid, total cholesterol and GGT are biomarkers that may increase in OSAS due to intermittent hypoxia with the involvement of other systems. Since a decrease in these biomarkers can be observed in the early period depending on treatment compliance, these biomarkers can be used practically in the follow-up of treatment compliance and treatment efficacy.
Sujet(s)

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Observance par le patient / Syndrome d&apos;apnées obstructives du sommeil / Ventilation en pression positive continue Limites: Adult / Female / Humans / Male / Middle aged Langue: En Journal: Tuberk Toraks Année: 2024 Type de document: Article Pays de publication: Turquie

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Observance par le patient / Syndrome d&apos;apnées obstructives du sommeil / Ventilation en pression positive continue Limites: Adult / Female / Humans / Male / Middle aged Langue: En Journal: Tuberk Toraks Année: 2024 Type de document: Article Pays de publication: Turquie