[Glymphatic dysfunction and sleep disorders: indirect effects on Alzheimer's disease]. / Glimfaticheskaya disfunktsiya i narusheniya sna: oposredovannoe vliyanie na bolezn' Al'tsgeimera.
Zh Nevrol Psikhiatr Im S S Korsakova
; 124(4): 7-12, 2024.
Article
de Ru
| MEDLINE
| ID: mdl-38676671
ABSTRACT
Modern research raises the question of the potentially significant role of glymphatic dysfunction in the development of neurodegeneration and pathological aging. The exact molecular mechanisms are not yet fully understood, but there is ample evidence of a link between sleep deprivation and decreased clearance of ß-amyloid and other neurotoxin proteins that are associated with the development of neurodegenerative diseases, particularly Alzheimer's disease. The review analyzes current scientific information in this area of research, describes the latest scientific discoveries of the features of the glymphatic system, and also illustrates studies of markers that presumably indicate a deterioration in the glymphatic system. The relationship between sleep deprivation and pathophysiological mechanisms associated with neurodegenerative diseases is considered, and potential targets that can be used to treat or delay the development of these disorders are noted.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Troubles de la veille et du sommeil
/
Peptides bêta-amyloïdes
/
Maladie d'Alzheimer
/
Système glymphatique
Limites:
Humans
Langue:
Ru
Journal:
Zh Nevrol Psikhiatr Im S S Korsakova
Sujet du journal:
NEUROLOGIA
/
PSIQUIATRIA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Russie
Pays de publication:
Russie