The genus Oxytropis DC: application, phytochemistry, pharmacology, and toxicity.
J Pharm Pharmacol
; 76(9): 1079-1114, 2024 Sep 03.
Article
de En
| MEDLINE
| ID: mdl-38687135
ABSTRACT
OBJECTIVES:
Oxytropis DC is a perennial plant of Fabaceae family, which is widely distributed in the northern temperate zone. It is known as "locoweed" because of its toxic component swainsonine. However, it is widely used in Tibetan medicine and Mongolian medicine, mainly for the treatment of heat-clearing and detoxifying, pain-relieving, anti-inflammatory, hemostasis, and other diseases. To provide a basis for the further development and utilization of Oxytropis DC, the pieces of literature about the application, phytochemistry, pharmacological action, and toxicity of Oxytropis DC were reviewed and analyzed. KEYFINDINGS:
A total of 373 chemical constituents were found from Oxytropis DC, including flavonoids, alkaloids, steroids, terpenoids, and others. Pharmacological actions mainly include antitumor, antioxidation, anti-inflammatory, analgesic, antibacterial, antifibrosis, and other pharmacological actions, among them, the antitumor effect is particularly prominent.SUMMARY:
At present, studies on its pharmacological effects are mainly concentrated on the extracts, some flavonoids, and alkaloids. In the follow-up studies, research on the pharmacological activities of the other chemical constituents in Oxytropis should be strengthened. It has the potential to pave the way for research and development of novel Oxytropis medicines.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Extraits de plantes
/
Oxytropis
Limites:
Animals
/
Humans
Langue:
En
Journal:
J Pharm Pharmacol
/
J. pharm. pharmacol
/
Journal of pharmacy and pharmacology
Année:
2024
Type de document:
Article
Pays de publication:
Royaume-Uni