Radiotherapy for patients with esophageal cancer aged 80 years or older: A 16-year experience.
J Cancer Res Ther
; 20(2): 678-683, 2024 Apr 01.
Article
de En
| MEDLINE
| ID: mdl-38687940
ABSTRACT
PURPOSE:
Radiotherapy (RT) plays an important role in esophageal cancer (EC) patients aged ≥80 years. However, the survival modality and prognostic factors remain poorly understood. Thus, this study aimed to evaluate the tolerance and long-term overall survival (OS) of patients aged ≥80 years who were diagnosed with EC and underwent definitive RT. MATERIALS ANDMETHODS:
A total of 213 consecutive patients with EC over 80 years old who were treated with curative intent RT between February 1999 and December 2015 at our institution were retrospectively reviewed. The clinical prognostic variables were analyzed against OS in univariate analyses using log-rank tests and in a multivariate model using Cox regression proportional hazards analysis.RESULT:
The median patient age was 82 (range 80-94) years. Atotal of 192 patients (90.1%) completed the definitive RT (median 60 Gy, range 50-72 Gy), and 11 patients had grade 4 or higher acute toxicity, including esophagitis, a cardiac event, infections, and sudden death. Atotal of 168 deaths (78.9%) were observed with a median follow up of 47 months (range 0-153 months). The OS rates were 50.3%, 17.6%, and 13.2% at 1, 3, and 5 years, respectively. Multivariable analysis identified that tumors located in the cervical and upper thorax, a shorter tumor lesion, RT treatment of 50-60Gy, and a better response to treatment were the factors associated with longer OS.CONCLUSION:
Definitive RT could be considered as an effective treatment for patients with EC who are older than 80 years, and 50-60 Gy seems to be a reasonable dose for these patients.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs de l'oesophage
Limites:
Aged80
/
Female
/
Humans
/
Male
Langue:
En
Journal:
J Cancer Res Ther
/
J. cancer res. ther
/
Journal of cancer research and therapeutics
Sujet du journal:
NEOPLASIAS
/
TERAPEUTICA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine
Pays de publication:
Inde