Structure-activity relationship in NOD2 agonistic muramyl dipeptides.
Eur J Med Chem
; 271: 116439, 2024 May 05.
Article
de En
| MEDLINE
| ID: mdl-38691886
ABSTRACT
Nucleotide-binding oligomerization domain 2 (NOD2) is a receptor of the innate immune system that is capable of perceiving bacterial and viral infections. Muramyl dipeptide (MDP, N-acetyl muramyl L-alanyl-d-isoglutamine), identified as the minimal immunologically active component of bacterial cell wall peptidoglycan (PGN) is recognized by NOD2. In terms of biological activities, MDP demonstrated vaccine adjuvant activity and stimulated non-specific protection against bacterial, viral, and parasitic infections and cancer. However, MDP has certain drawbacks including pyrogenicity, rapid elimination, and lack of oral bioavailability. Several detailed structure-activity relationship (SAR) studies around MDP scaffolds are being carried out to identify better NOD2 ligands. The present review elaborates a comprehensive SAR summarizing structural aspects of MDP derivatives in relation to NOD2 agonistic activity.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Acétylmuramyl alanyl isoglutamine
/
Protéine adaptatrice de signalisation NOD2
Limites:
Animals
/
Humans
Langue:
En
Journal:
Eur J Med Chem
Année:
2024
Type de document:
Article
Pays d'affiliation:
Inde
Pays de publication:
France