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Clinical, molecular, and drug resistance epidemiology of HIV in Jordan, 2019-2021: A national study.
Bakri, Faris G; Mukattash, Heyam H; Esmeiran, Hiam; Schluck, Glenna; Storme, Casey K; Broach, Erica; Mebrahtu, Tsedal; Alhawarat, Mohammad; Valencia-Ruiz, Anais; M'Hamdi, Oussama; Malia, Jennifer A; Hassen, Zebiba; Shafei, Mah'd M S; Alkhatib, Ala Y; Gazo, Mahmoud; Jaradat, Saied A; Gomez, Yessenia; McGeehon, Samantha; McCauley, Melanie D; Moreland, Sarah C; Darden, Janice M; Amare, Mihret; Crowell, Trevor A; Vasan, Sandhya; Michael, Nelson L; Ake, Julie A; Modjarrad, Kayvon; Scott, Paul T; Peel, Sheila A; Hakre, Shilpa.
Affiliation
  • Bakri FG; Division of Infectious Diseases, Department of Internal Medicine, Jordan University Hospital, Amman, Jordan; Infectious Diseases and Vaccine Center, University of Jordan, Amman, Jordan.
  • Mukattash HH; Primary Health Care Directorate, Ministry of Health, Amman, Jordan.
  • Esmeiran H; HJF Medical Research International (HJFMRI), Amman, Jordan.
  • Schluck G; Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD.
  • Storme CK; Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD.
  • Broach E; Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD.
  • Mebrahtu T; Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD.
  • Alhawarat M; Communicable Diseases Directorate, Ministry of Health, Amman, Jordan.
  • Valencia-Ruiz A; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD; Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD.
  • M'Hamdi O; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD; Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD.
  • Malia JA; Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD.
  • Hassen Z; Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD.
  • Shafei MMS; Central Public Health Laboratory, Ministry of Health, Amman, Jordan.
  • Alkhatib AY; Voluntary Counselling and Testing Center, Ministry of Health, Amman, Jordan.
  • Gazo M; Central Public Health Laboratory, Ministry of Health, Amman, Jordan.
  • Jaradat SA; Princess Haya Biotechnology Center, Jordan University of Science and Technology, Irbid, Jordan.
  • Gomez Y; Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD.
  • McGeehon S; Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD.
  • McCauley MD; Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD.
  • Moreland SC; Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD.
  • Darden JM; Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD; Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD.
  • Amare M; Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD.
  • Crowell TA; Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD.
  • Vasan S; Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD.
  • Michael NL; Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD.
  • Ake JA; United States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD.
  • Modjarrad K; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD.
  • Scott PT; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD.
  • Peel SA; Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD.
  • Hakre S; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD. Electronic address: shakre@eidresearch.org.
Int J Infect Dis ; 145: 107079, 2024 Aug.
Article de En | MEDLINE | ID: mdl-38697607
ABSTRACT

BACKGROUND:

Limited epidemiologic studies have been conducted in Jordan describing the HIV epidemic. This study aimed to address this gap to inform HIV prevention and control.

METHODS:

A nationally-representative cross-sectional study was conducted among adults living with HIV in Jordan. Laboratory testing included HIV viral load and next-generation-sequencing-based clinical genotype. Log-binomial regression estimated risk ratios (RRs) and 95% confidence intervals (CIs).

RESULTS:

Among 231 (70%) participants, most were male (184/80%), and from Jordan (217/94%). Among 188 treatment-experienced-participants (>6 months), 165 (88%) were virally suppressed. High-level resistance was most frequent against nucleoside reverse transcriptase inhibitor (13/81%), and integrase-strand transfer inhibitor (INSTI) (10/62%) drugs among viremic (≥1000 HIV copies/mL) treatment-experienced participants with drug-resistant mutations (DRMs, n = 16). Common HIV subtypes (n = 43) were B (6/14%), A1 (5/12%), and CRF01_AE (5/12%); additionally, novel recombinant forms were detected. In multivariate analysis, independently higher risk for late diagnosis (n = 49) was observed with diagnosis through blood donation (vs check-up RR 2.20, 95%CI 1.16-4.17) and earlier time-period of diagnosis (1986-2014 vs 2015-2021 RR 2.87, 95%CI 1.46-5.62).

CONCLUSIONS:

Late diagnosis and INSTI resistance endanger national HIV prevention and treatment in Jordan-high-level resistance to INSTI suggests therapeutic drug monitoring is needed for treatment efficacy and conservation of treatment options.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Infections à VIH / Agents antiVIH / Charge virale / Résistance virale aux médicaments Limites: Adolescent / Adult / Female / Humans / Male / Middle aged Pays/Région comme sujet: Asia Langue: En Journal: Int J Infect Dis Sujet du journal: DOENCAS TRANSMISSIVEIS Année: 2024 Type de document: Article Pays d'affiliation: Jordanie
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Infections à VIH / Agents antiVIH / Charge virale / Résistance virale aux médicaments Limites: Adolescent / Adult / Female / Humans / Male / Middle aged Pays/Région comme sujet: Asia Langue: En Journal: Int J Infect Dis Sujet du journal: DOENCAS TRANSMISSIVEIS Année: 2024 Type de document: Article Pays d'affiliation: Jordanie