Microbial metabolite steers intestinal stem cell fate under stress.
Cell Stem Cell
; 31(5): 591-592, 2024 May 02.
Article
de En
| MEDLINE
| ID: mdl-38701755
ABSTRACT
Recently in Cell Metabolism, Wei et al.1 unveiled a brain-to-gut pathway that conveys psychological stress to intestinal epithelial cells, leading to their dysfunction. This gut-brain axis involves a microbial metabolite, indole-3-acetate (IAA), as a niche signal that hampers mitochondrial respiration to skew intestinal stem cell (ISC) fate.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cellules souches
Limites:
Animals
/
Humans
Langue:
En
Journal:
Cell Stem Cell
Année:
2024
Type de document:
Article