Microbial metabolite steers intestinal stem cell fate under stress.

Zhu, Shu; Pan, Wen

Zhu, Shu; Pan, Wen.

Affiliation

Zhu S; Department of Digestive Disease, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China; Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. Electronic address: z
Pan W; Department of Digestive Disease, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China; Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. Electronic address: w

Cell Stem Cell ; 31(5): 591-592, 2024 May 02.

Article de En | MEDLINE | ID: mdl-38701755

ABSTRACT

ABSTRACT

Recently in Cell Metabolism, Wei et al.1 unveiled a brain-to-gut pathway that conveys psychological stress to intestinal epithelial cells, leading to their dysfunction. This gut-brain axis involves a microbial metabolite, indole-3-acetate (IAA), as a niche signal that hampers mitochondrial respiration to skew intestinal stem cell (ISC) fate.

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Cellules souches Limites: Animals / Humans Langue: En Journal: Cell Stem Cell Année: 2024 Type de document: Article

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