Highly local activation of inhibition at the seizure wavefront in vivo.
Cell Rep
; 43(5): 114189, 2024 May 28.
Article
de En
| MEDLINE
| ID: mdl-38703365
ABSTRACT
The propagation of a seizure wavefront in the cortex divides an intensely firing seizure core from a low-firing seizure penumbra. Seizure propagation is currently thought to generate strong activation of inhibition in the seizure penumbra that leads to its decreased neuronal firing. However, the direct measurement of neuronal excitability during seizures has been difficult to perform in vivo. We used simultaneous optogenetics and calcium imaging (all-optical interrogation) to characterize real-time neuronal excitability in an acute mouse model of seizure propagation. We find that single-neuron excitability is decreased in close proximity to the seizure wavefront but becomes increased distal to the seizure wavefront. This suggests that inhibitory neurons of the seizure wavefront create a proximal circumference of hypoexcitability but do not influence neuronal excitability in the penumbra.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Crises épileptiques
Limites:
Animals
Langue:
En
Journal:
Cell Rep
Année:
2024
Type de document:
Article
Pays d'affiliation:
Canada