[The role of Th17 cells and IL-17 in Hashimoto's thyroiditis: Review].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
; 40(4): 373-377, 2024 Apr.
Article
de Zh
| MEDLINE
| ID: mdl-38710521
ABSTRACT
Patients with Hashimoto's thyroiditis had increased numbers of Th17 cells in serum and thyroid tissue, significantly elevated levels of interleukin 17 (IL-17), and an imbalance in the ratio of Th17 cells to regulatory T cells (Tregs). The reduced Tregs' ratio leads to a reduction in immunosuppressive function within the thyroid gland, while Th17 cells are involved in the development of HT by regulating the expression of pro-inflammatory cytokines in the thyroid gland and mediating thyroid tissue fibrosis through the secretion of IL-17.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Lymphocytes T régulateurs
/
Interleukine-17
/
Maladie de Hashimoto
/
Cellules Th17
Limites:
Animals
/
Humans
Langue:
Zh
Journal:
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
Sujet du journal:
ALERGIA E IMUNOLOGIA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine