Single-cell transcriptomics reveals a role for pancreatic duct cells as potential mediators of inflammation in diabetes mellitus.
Front Immunol
; 15: 1381319, 2024.
Article
de En
| MEDLINE
| ID: mdl-38742118
ABSTRACT
Introduction:
Inflammation of the pancreas contributes to the development of diabetes mellitus. Although it is well-accepted that local inflammation leads to a progressive loss of functional beta cell mass that eventually causes the onset of the disease, the development of islet inflammation remains unclear.Methods:
Here, we used single-cell RNA sequencing to explore the cell type-specific molecular response of primary human pancreatic cells exposed to an inflammatory environment.Results:
We identified a duct subpopulation presenting a unique proinflammatory signature among all pancreatic cell types.Discussion:
Overall, the findings of this study point towards a role for duct cells in the propagation of islet inflammation, and in immune cell recruitment and activation, which are key steps in the pathophysiology of diabetes mellitus.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Conduits pancréatiques
/
Analyse sur cellule unique
/
Transcriptome
/
Inflammation
Limites:
Humans
Langue:
En
Journal:
Front Immunol
Année:
2024
Type de document:
Article
Pays d'affiliation:
Pays-Bas