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Radiopharmaceuticals for Cancer Diagnosis and Therapy: New Targets, New Therapies-Alpha-Emitters, Novel Targets.
Taunk, Neil K; Escorcia, Freddy E; Lewis, Jason S; Bodei, Lisa.
Affiliation
  • Taunk NK; From the Department of Radiation Oncology and Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
  • Escorcia FE; Molecular Imaging Branch, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
  • Lewis JS; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Bodei L; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY.
Cancer J ; 30(3): 218-223, 2024.
Article de En | MEDLINE | ID: mdl-38753757
ABSTRACT
ABSTRACT Radiopharmaceutical therapy has emerged as a promising approach for the treatment of various cancers. The exploration of novel targets such as tumor-specific antigens, overexpressed receptors, and intracellular biomolecules using antibodies, peptides, or small molecules has expanded the scope of radiopharmaceutical therapy, enabling precise and effective cancer treatment for an increasing number of tumor types. Alpha emitters, characterized by their high linear energy transfer and short path length, offer unique advantages in targeted therapy due to their potent cytotoxicity against cancer cells while sparing healthy tissues. This article reviews recent advancements in identifying novel targets for radiopharmaceutical therapy and applications in utilizing α-emitters for targeted treatment.
Sujet(s)

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Radiopharmaceutiques / Tumeurs Limites: Animals / Humans Langue: En Journal: Cancer J Sujet du journal: NEOPLASIAS Année: 2024 Type de document: Article Pays d'affiliation: Panama

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Radiopharmaceutiques / Tumeurs Limites: Animals / Humans Langue: En Journal: Cancer J Sujet du journal: NEOPLASIAS Année: 2024 Type de document: Article Pays d'affiliation: Panama