Your browser doesn't support javascript.
loading
Oxidative stress and neurodegenerative diseases: a bidirectional Mendelian randomization study.
Yin, Zihan; Yang, Zuoqin; Liu, Yiwei; Zhao, Ling; Liang, Fanrong.
Affiliation
  • Yin Z; School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
  • Yang Z; Acupuncture Clinical Research Center of Sichuan Province, Chengdu, People's Republic of China.
  • Liu Y; Acupuncture Department, Traditional Chinese Medicine Hospital of Pidu district, Chengdu, People's Republic of China.
  • Zhao L; Rehabilitation Department, the West China Hospital, Chengdu, People's Republic of China.
  • Liang F; School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Nutr Neurosci ; : 1-9, 2024 May 16.
Article de En | MEDLINE | ID: mdl-38753998
ABSTRACT

INTRODUCTION:

Oxidative stress (OS) has been linked to neurodegenerative diseases in numerous epidemiological studies; however, whether it is a pathogenesis or a downstream factor remains controversial.

METHODS:

A two-sample bidirectional Mendelian randomization (MR) analysis was implemented to examine evidence of causality of 15 OS injury markers with 3 major neurodegenerative diseases using available genome-wide association studies statistics. As a main approach, inverse-variance weighted (IVW) analysis was performed. The weighted-median (WM) analysis was used to validate the relationship. In order to investigate the existence of horizontal pleiotropy and correct the IVW estimate, the Radial MR approach was applied. To gauge the consistency and robustness of the findings, several sensitivity and pleiotropy analyses were used. For this analysis, p < 0.05 indicates a nominally causal association; according to the Bonferroni correction test, p < 0.0011 indicates a statistically significant causal association.

RESULTS:

Via IVW and WM, in directional MR, it was genetically predicted that zinc was nominally causally correlated with the risk of Parkinson's disease but not after Bonferroni correction test; alpha-tocopherol was nominally causally correlated with the risk of Amyotrophic lateral sclerosis (ALS) but not after Bonferroni correction test; furthermore, in reverse MR, it was genetically predicted that Alzheimer's disease was causally correlated with uric acid but not after Bonferroni correction test. These above findings were stable across sensitivity and pleiotropy analyses.

CONCLUSIONS:

Based on the current study, there is no authentic genetic causal association between OS biomarkers and neurodegenerative diseases. The complex relationship is required to be confirmed in future experimental research.
Mots clés

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: Nutr Neurosci Sujet du journal: CIENCIAS DA NUTRICAO / NEUROLOGIA Année: 2024 Type de document: Article

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: Nutr Neurosci Sujet du journal: CIENCIAS DA NUTRICAO / NEUROLOGIA Année: 2024 Type de document: Article
...