FOXP3 gene is associated with susceptibility to ischemic stroke in the Chinese population.
Clin Neurol Neurosurg
; 242: 108313, 2024 07.
Article
de En
| MEDLINE
| ID: mdl-38754303
ABSTRACT
AIM:
Immunoinflammatory response plays an important role in the pathophysiological process of ischemic stroke (IS). Forkhead box P3 (FOXP3) is a master regulator for immune cells. Polymorphisms of FOXP3 gene might contribute to the susceptibility of IS. This study aimed to explore the association between FOXP3 gene polymorphisms (rs3761548 and rs2232365) and IS susceptibility in the Chinese Han population.METHODS:
Polymerase chain reaction and Sanger sequencing were used to detect the genotype of FOXP3 gene rs3761548 and rs2232365 polymorphisms.RESULTS:
Smoking, diabetes mellitus (DM), and HBP histories, higher TG and HDL-C levels were more frequently observed in IS patients than in controls. In comparison with rs3761548 GG genotype, GT genotype (ORâ¯=â¯1.573, 95â¯%CIâ¯= 1.030-2.402; adjusted ORâ¯=â¯1.736, 95â¯%CIâ¯= 1.070-2.817) and GTâ¯+â¯TT vs. GG model (ORâ¯=â¯1.581, 95â¯%CIâ¯= 1.0449-2.382; adjusted ORâ¯=â¯1.720, 95â¯%CIâ¯=â¯1.074-2.755) of rs3761548 polymorphism was significantly correlated with elevated ischemic stroke susceptibility both at prior and after adjusted by smoking, HBP, DM, TG and HDL-C. Recessive model of rs2232365 polymorphism could elevate the susceptibility of ischemic stroke (ORâ¯=â¯11.962, 95â¯%CIâ¯= 1.144-3.3363; adjusted ORâ¯=â¯1.876, 95â¯%CIâ¯= 1.016-3.463). Besides, rs3761548 dominant model (ORâ¯=â¯2.757, 95â¯%CIâ¯= 1.379-5.552; adjusted ORâ¯=â¯2.601, 95â¯%CIâ¯= 1.268-5.336) and rs2232365 recessive model (ORâ¯=â¯3.103, 95â¯%CIâ¯= 1.463-6.583; adjusted ORâ¯=â¯3.545, 95â¯%CIâ¯= 1.600-7.855) were related to the severity of ischemic stroke.CONCLUSION:
FOXP3 gene rs3761548 and rs2232365 polymorphisms were risk factors for susceptibility and severity of IS.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Prédisposition génétique à une maladie
/
Polymorphisme de nucléotide simple
/
Facteurs de transcription Forkhead
/
Accident vasculaire cérébral ischémique
Limites:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
Clin Neurol Neurosurg
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine