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Intratumoral metabolic heterogeneity by 18F-FDG PET/CT to predict prognosis for patients with thymic epithelial tumors.
Chao, Fangfang; Wang, Ran; Han, Xingmin; Huang, Wenpeng; Wang, Ruihua; Yu, Yanxia; Lin, Xuyang; Yuan, Ping; Yang, Meng; Gao, Jianbo.
Affiliation
  • Chao F; Department of Nuclear Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Wang R; Department of Nuclear Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Han X; Department of Nuclear Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Huang W; Department of Nuclear Medicine, Peking University First Hospital, Beijing, China.
  • Wang R; Department of Nuclear Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Yu Y; Department of Nuclear Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Lin X; Department of Nuclear Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Yuan P; Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Yang M; Department of Nuclear Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Gao J; Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Thorac Cancer ; 15(18): 1437-1445, 2024 Jun.
Article de En | MEDLINE | ID: mdl-38757212
ABSTRACT

BACKGROUND:

The aim of the present study was to evaluate the impact of intratumoral metabolic heterogeneity and quantitative 18F-FDG PET/CT imaging parameters in predicting patient outcomes in thymic epithelial tumors (TETs).

METHODS:

This retrospective study included 100 patients diagnosed with TETs who underwent pretreatment 18F-FDG PET/CT. The maximum and mean standardized uptake values (SUVmax and SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) on PET/CT were measured. Heterogeneity index-1 (HI-1; standard deviation [SD] divided by SUVmean) and heterogeneity index-2 (HI-2; linear regression slopes of the MTV according with different SUV thresholds), were evaluated as heterogeneity indices. Associations between these parameters and patient survival outcomes were analyzed.

RESULTS:

The univariate analysis showed that Masaoka stage, TNM stage, WHO classification, SUVmax, SUVmean, TLG, and HI-1 were significant prognostic factors for progression-free survival (PFS), while MTV, HI-2, age, gender, presence of myasthenia gravis, and maximum tumor diameter were not. Subsequently, multivariate analyses showed that HI-1 (p < 0.001) and TNM stage (p = 0.002) were independent prognostic factors for PFS. For the overall survival analysis, TNM stage, WHO classification, SUVmax, and HI-1 were significant prognostic factors in the univariate analysis, while TNM stage remained an independent prognostic factor in multivariate analyses (p = 0.024). The Kaplan Meier survival analyses showed worse prognoses for patients with TNM stages III and IV and HI-1 ≥ 0.16 compared to those with stages I and II and HI-1 < 0.16 (log-rank p < 0.001).

CONCLUSION:

HI-1 and TNM stage were independent prognostic factors for progression-free survival in TETs. HI-1 generated from baseline 18F-FDG PET/CT might be promising to identify patients with poor prognosis.
Sujet(s)

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tumeurs du thymus / Tumeurs épithéliales épidermoïdes et glandulaires / Fluorodésoxyglucose F18 / Tomographie par émission de positons couplée à la tomodensitométrie Limites: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Langue: En Journal: Thorac Cancer Année: 2024 Type de document: Article Pays d'affiliation: Chine Pays de publication: Singapour

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tumeurs du thymus / Tumeurs épithéliales épidermoïdes et glandulaires / Fluorodésoxyglucose F18 / Tomographie par émission de positons couplée à la tomodensitométrie Limites: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Langue: En Journal: Thorac Cancer Année: 2024 Type de document: Article Pays d'affiliation: Chine Pays de publication: Singapour